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By Mostafa Abo Elsoud (National Research Center, Egypt)

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Model of SOS-induced mutagenesis in bacteria Escherichia coli under ultraviolet irradiation. By Mostafa Abo Elsoud (National Research Center, Egypt). Supervised by Marina L yashko Svetlana Aksenova. Laboratory of Radiation Biology (LRB), JINR, Russia.

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slide1
Model of SOS-induced mutagenesis in bacteria Escherichia coli under ultraviolet irradiation

By

MostafaAboElsoud

(National Research Center, Egypt)

Supervised by

Marina Lyashko

Svetlana Aksenova

Laboratory of Radiation Biology (LRB), JINR, Russia.

slide2
The SOS response in Escherichia coli bacteria is a set of inducible physiological reactions that help a cell to survive after the treatment with various DNA-damaging agents, such as ultraviolet, ionizing radiation and some chemicals.
  • More than 40 genes are induced in response to DNA damage as part of the SOS regulonin Escherichia coli.
  • SOS repair may result in SOS mutagenesis due to the inhibition of the proofreading activity of the epsilon subunit of DNA Pol III.
slide3
Cyclobutane pyrimidinedimers (CPD)

And

pyrimidinepyrimidone photoproduct (6-4 PP)

Lex A

UV

RecA

Umuc, UmuD, DinI

SOS gene box

RecA*

Mechanism of SOS repair system activation

slide4
ssDNA+RecA+ATP

Mechanism of

SOS repair system

RecA*

DinI

LexA

UmuD

UmuD’

.

umuC

umuD

dinI

.

UmuD2

UmuDD’

UmuD’2

UmuC

UmuD2C

UmuD’2C

UmuDD’C

Pol V

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