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Monitoring spike train synchrony

Thomas Kreuz Institute for complex systems, CNR Florence, Italy. Monitoring spike train synchrony. June 2013. Example movie Time-resolved spike train distances - (ISI-distance) - SPIKE-distance - Realtime SPIKE-distance Application to multi-unit activity from epilepsy patients

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Monitoring spike train synchrony

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  1. Thomas Kreuz Institute for complex systems, CNR Florence, Italy Monitoringspike train synchrony June 2013

  2. Example movie Time-resolved spike train distances - (ISI-distance) - SPIKE-distance - Realtime SPIKE-distance Application to multi-unit activity from epilepsy patients Application to continuous data (EEG) Outline

  3. Example movie Time-resolved spike train distances - (ISI-distance) - SPIKE-distance - Realtime SPIKE-distance Application to multi-unit activity from epilepsy patients Application to continuous data (EEG) Outline

  4. Movie“Instantaneous clustering 1”

  5. Example movie Time-resolved spike train distances - (ISI-distance) - SPIKE-distance (improved) - Realtime SPIKE-distance Application to multi-unit activity from epilepsy patients Application to continuous data (EEG) Outline

  6. ISI- and SPIKE-distance Average over time profiles: Instantaneous values Time of previous spike: Time of following spike: Interspike interval: n=1,2 (spike trains)

  7. Notation

  8. Notation

  9. Example movie Time-resolved spike train distances - (ISI-distance) - SPIKE-distance - Realtime SPIKE-distance Application to multi-unit activity from epilepsy patients Application to continuous data (EEG) Outline

  10. ISI-distance: Notation

  11. ISI-distance Bivariate (N=2) Kreuz et al., J Neurosci Methods (2007)

  12. Bivariate ISI-Distance: High synchrony

  13. Bivariate ISI-Distance: Low synchrony

  14. ISI-distance Multivariate (N>2): Local pairwise averages Kreuz et al., J Neurosci Methods (2009) Analogous equation holds for SPIKE-distance

  15. Example movie Time-resolved spike train distances - (ISI-distance) - SPIKE-distance - Realtime SPIKE-distance Application to multi-unit activity from epilepsy patients Application to continuous data (EEG) Outline

  16. ISI- vs. SPIKE-distance

  17. SPIKE-distance

  18. SPIKE-distance

  19. SPIKE-distance

  20. SPIKE-distance

  21. SPIKE-distance

  22. SPIKE-distance

  23. SPIKE-distance

  24. SPIKE-distance For each corner spike: Interval to nearest spike in other spike train

  25. SPIKE-distance Local weighting (for each spike train separately) Interval to previous spikes: Interval to following spikes: e.g. Kreuz et al., J Neurosci Methods (2011)

  26. SPIKE-distance Averaging and normalization (Time-scale independence): Weighting of relative distances between spike trains: Kreuz et al., submitted (2012)

  27. SPIKE-distance

  28. SPIKE-distance

  29. Example movie Time-resolved spike train distances - (ISI-distance) - SPIKE-distance - Realtime SPIKE-distance Application to multi-unit activity from epilepsy patients Application to continuous data (EEG) Outline

  30. Real-time SPIKE-distance Motivation: • Epilepsy • Brain-Machine Interfaces No following spikes, no ISI Kreuz et al., submitted (2012)

  31. Real-time SPIKE-distance

  32. Real-time SPIKE-distance

  33. Real-time SPIKE-distance: Peaks not spurious

  34. Clustering I

  35. Clustering II

  36. Selected averaging

  37. Triggered averaging I

  38. Triggered averaging II

  39. Population averages

  40. Movie“Instantaneous clustering 2”

  41. Example movie Time-resolved spike train distances - (ISI-distance) - SPIKE-distance - Realtime SPIKE-distance Application to multi-unit activity from epilepsy patients Application to continuous data (EEG) Outline

  42. Epilepsy Statistics • ~ 1 % of world population suffers from epilepsy • in Germany ~ 800 000 patients • ~ 70 % can be treated with antiepileptic drugs • ~ 8 % might profit from epilepsy surgery • ~ 22 % cannot be treated sufficiently Epilepsy Center Bonn (Contact: Florian Mormann) • presurgical evaluations: ~ 50 cases / year • invasive evaluations: ~ 15 cases / year

  43. Presurgical evaluation - Localization of seizure generating area (epileptic focus) - current gold standard: EEG recording of seizure origin - exact delineation from functionally relevant areas - estimation of post-operative status (seizure control, neurological deficits, ...) Surgical intervention - tailored resection of epileptic focus Epilepsy Surgery

  44. Hippocampus Amygdala Entorhinal Cortex Medial Temporal Lobe Parahippocampal Cortex

  45. Implanted Electrodes

  46. Clinical contacts Microwire recordings in humans • 64 microwires (40 μm diameter) able to • record single-neuron-activity and LFPs • Effective recording bandwidth 1 Hz - 10 kHz • Data provided by Florian Mormann Setup:

  47. Action potentials of individual neurons Quian Quiroga, Scholarpedia (2007)

  48. Movie“Epileptic seizure”

  49. Example movie Time-resolved spike train distances - (ISI-distance) - SPIKE-distance - Realtime SPIKE-distance Application to multi-unit activity from epilepsy patients Application to continuous data (EEG) Outline

  50. Continuous data

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