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End-of-life Care in the ICU: Practical and Ethical Issues

. . . . . . . . . . . . . . . Case Scenario. An 85-year-old man with New York Heart Association class IV heart failure, hypertension, and moderate Alzheimer's disease is admitted to the hospital after a hip fracture.His postoperative course is complicated by pneumonia, delirium, and pressure ulcers on his heels and sacrum. Respiratory status is worsened with severe shortness of breath and hypoxemia requiring high flow O2 .A decision for intubation and mechanical ventilation needs to be made.34556

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End-of-life Care in the ICU: Practical and Ethical Issues

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    1. End-of-life Care in the ICU: Practical and Ethical Issues Mazen Kherallah, MD, FCCP

    11. Case Scenario An 85-year-old man with New York Heart Association class IV heart failure, hypertension, and moderate Alzheimer’s disease is admitted to the hospital after a hip fracture. His postoperative course is complicated by pneumonia, delirium, and pressure ulcers on his heels and sacrum. Respiratory status is worsened with severe shortness of breath and hypoxemia requiring high flow O2 . A decision for intubation and mechanical ventilation needs to be made

    12. What would you do next: Intubate the patient and place on MV Do not intubate and Inform the family that prognosis is bad based on his previous condition Meet with the family and ask them what they want to do and proceed based on their wishes Meet the family and help in making decision: shared decision making

    13. Palliative care within the experience of illness, bereavement, and risk.

    14. One in Five Deaths in the U.S. Occur in the ICU

    15. Proportion of Deaths Preceded by CPR for Patients > 65 years old

    16. Variability in Withholding and Withdrawing Life Support in the US

    17. Outline Shared decision-making Tools for communicating with families Interdisciplinary communication Role of culture and ethnicity Withdrawing life support

    18. What Do We Know About Shared Decision-making in the ICU? <5% of patients can participate in ICU decisions about withholding treatments Communication is primarily with family Families rate communication as of equal or more importance than clinical skill Families under immense burdens High level of anxiety and depression

    19. Shared Decision-making About End-of-life Care

    20. Family Preferences for Role in Decision-making

    21. Symptoms of PTSD Higher with Discordance in Decision-making Role

    22. New Paradigm for “Right Approach” to Parentalism vs. Autonomy

    23. New Paradigm for “Right Approach” to Parentalism vs. Autonomy

    24. When Should We Involve Families in Decisions about Life Support? Not after the ICU team has decided it is time to withdraw life support Discussions with ICU team should occur on ICU admission Review prognosis and potential outcomes Bring family along with us as things change Discussion with other clinicians should occur prior to ICU admission

    25. Outline Shared decision-making Tools for communicating with families Interdisciplinary communication Role of culture and ethnicity Withdrawing life support

    26. Case Scenario 69 year old with PMH of HTN, DM, and COPD Admitted with pneumonia and required to be intubated and placed on MV Condition is worsened with shock, renal failure requiring dialysis, DIC, severe ARDS and lactic acidosis (LA 8.9)

    27. What would you do next: Continue current level of support, do not dialyze and no escalation of inotrops Discontinue all life support modalities and provide comfort care Escalate therapies, start hemodialysis, and do everything possible. Arrange for family conference and discuss the current condition, prognosis and expectation with the family and make a shared decision

    28. Study of ICU Family Conferences Daily screen of all ICUs in 4 hospitals If conference planned, contact attending: Is discussion of withholding or withdrawing life support likely? Willing to have conference recorded? Consent/survey all participants 51 family conferences recorded (46%)

    29. Duration of Family Conferences and Proportion of Family Speech

    30. Proportion Family Speech Correlates with Family Satisfaction

    31. Clinician Statements Associated with Increased Family Satisfaction Assure family that patient will not be abandoned prior to death Assure family that patient will be kept comfortable and not suffer prior to death Provide support for family around decisions to withdraw or continue life support Answer questions, clarify and follow up on family statements Acknowledge and address emotions Explore patient preferences Affirm non-abandonment

    32. VALUE: 5-step Approach to Improving Communication in ICU with Families V… Value family statements A… Acknowledge family emotions L… Listen to the family U… Understand patient as a person E… Elicit family questions

    33. Missed Opportunities During ICU Family Conferences Listen and respond Answer questions Clarify and follow up on family statements Acknowledge and address emotions Address tenets of palliative care Explore patient preferences Explain surrogate decision-making Affirm non-abandonment

    35. Randomized Trial of Communication Strategy

    36. Family Member Outcomes: Clinically Significant Morbidity at 3 Months

    37. Outline Shared decision-making Tools for communicating with families Interdisciplinary communication Role of culture and ethnicity Withdrawing life support

    38. A meeting is scheduled, whom do want to be present? Yourself and patient’s wife Yourself, wife and closed relatives Yourself, wife, closed relatives and the primary physician Yourself, wife, closed relatives, primary physician and the nurse Yourself, wife, closed relatives, primary physician, the nurse and a religious person

    39. Physician-Nurse Collaboration in the ICU Interdisciplinary collaboration associated with decreased ICU mortality ICU length of stay ICU readmission rates Physician and nurse conflict Job stress for nurses

    40. Doctor and Nurse Ratings of Interdisciplinary Communication

    41. Percent of Decisions with Physician-Nurse Collaboration in Decision-making

    42. Percent of Physicians Involving Nurses in Decisions about Withdrawal

    43. How do you assess the physician collaboration? (Nurses only) Poor Average Good Very good Excellent

    44. How do you assess the nurses collaboration? (Physicians only) Poor Average Good Very good Excellent

    45. Outline Shared decision-making Tools for communicating with families Interdisciplinary communication Role of culture and ethnicity Withdrawing life support

    46. Case Scenario 54 year old male with 30 years of smoking history who was recently diagnosed with metastatic lung cancer The wife request not to inform the patient with his diagnosis or prognosis

    47. What would you do next? Tell the wife that it is his right to know the diagnosis and prognosis and inform the patient Respect the wife’s wish and tell the patient that he has pneumonia and treatment will be given to him Inform the wife to follow with other physician as you would not be able to carry on with her wish but do not inform the patient

    48. In your opinion, should a patient be told of a cancer Dx? Yes No

    49. In your opinion, should a patient decide about withdrawing life support treatment? Yes No

    50. Cultural Differences: Survey of 800 Patients in LA

    51. Outline Shared decision-making Tools for communicating with families Interdisciplinary communication Role of culture and ethnicity Withdrawing life support

    52. A decision is made to withdraw LST, how would you do it? Do not escalate treatment, do no labs and continue with meds, fluids and feeding Do no labs, stop all medications except sedatives and analgesia and stop fluids and feeding Stop everything, sedate patient and extubate Stop everything, sedate patient and do terminal wean

    53. Needs of the Patient Receiving adequate pain and symptom management. Avoiding inappropriate prolongation of dying Achieving a sense of control Relieving burden Strengthening relationships with loved ones.

    54. Needs of Families

    55. Components of the Withdrawal of Life Support Form Preparation DNAR order; document discussion with family; discontinue prior orders Ventilator withdrawal protocol Analgesia and sedation Infusion with broad range; no maximum dose; document reason for increase Principles of withdrawing life support

    56. Terminal Withdrawal of the Ventilator

    57. Opioid Analgesics

    58. Sedative Agents

    59. Should Patients Be Extubated After Withdrawing Mechanical Ventilation? Yes No

    60. Should Patients Be Extubated After Withdrawing Mechanical Ventilation? Little evidence to guide decisions Clinicians often have strong opinions Recent study suggests family ratings of care higher if patient extubated Case-based judgment based on Family preferences Level of support, amount of secretions, level of consciousness

    61. Tips for Talking with Family About Withdrawal of Life Support When life support is withdrawn, stress “Care” will not be withdrawn Aggressive palliation will be used avoid making firm predictions about the patient’s clinical course Time to death variable Offer option of family being present Family presence associated with higher PTSD Describe process so they know what to expect

    63. Summary: Ethical and Practical Issues in End-of-life Care in the ICU Decision-making about end-of-life care common in the ICU and should start early Shared decision-making at the default Need to adapt to individual patient and family Interdisciplinary communication essential Incorporate and honor cultural difference Withdrawal of life support is a clinical procedure

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