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Ronco (ref 2) 425 CVVH 20/h vs. 35-45 ml/kg/h*

Supplementary Figure 1: Forest plot pooling trials of RRT dose. Study n treatment groups. Ronco (ref 2) 425 CVVH 20/h vs. 35-45 ml/kg/h*. Bouman (ref 4) 106 CVVH 20ml/kg/h* vs. 48 ml/kg/h. Schiffl (ref 3) 160 Alternate day vs. daily hemodialysis.

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Ronco (ref 2) 425 CVVH 20/h vs. 35-45 ml/kg/h*

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  1. Supplementary Figure 1: Forest plot pooling trials of RRT dose Study n treatment groups Ronco (ref 2) 425 CVVH 20/h vs. 35-45 ml/kg/h* Bouman (ref 4) 106 CVVH 20ml/kg/h* vs. 48 ml/kg/h Schiffl (ref 3) 160 Alternate day vs. daily hemodialysis Saudan 206 CVVH 25 ml/kg/h vs. CVVHDF 42 ml/kg/h Total (fixed effects) Total (random effects) 1 10 Odds ratio *For purposes of analysis the two high-dose arms in Ronco were combined, as were the two low-dose arms in Bouman. If these groups are removed the odds ratio is unchanged (1.94; P <0.001).

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