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Chelation and Hyperbaric Oxygen Therapies - Treatment for Autism?

By: Nancy Lorenzini. Chelation and Hyperbaric Oxygen Therapies - Treatment for Autism?. Where Did I Go For Information. Search Engines: Psych info, Proquest Research Library, Health Reference Center, Health Wellness Resource Center, PsychArticles, Science Digest, and Google. Search Terms:

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Chelation and Hyperbaric Oxygen Therapies - Treatment for Autism?

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  1. By: Nancy Lorenzini Chelation and Hyperbaric Oxygen Therapies -Treatment for Autism?

  2. Where Did I Go For Information • Search Engines: • Psych info, Proquest Research Library, Health Reference Center, Health Wellness Resource Center, PsychArticles, Science Digest, and Google Search Terms: Chelation and autism Chelation therapy Thimerosal and autism Mercury and autism Alternative Therapies and autism Autistic Spectrum Disorders (ASD) Autism Treatments Vaccines and autism Developmental Disabilities Search Terms: Hyperbaric Oxygen Therapy ad autism HBOT Hyperbaric Oxygen Therapy Hyperbaric Chamber, Hyperbaric Oxygen Treatment Autistic Spectrum Disorders and Hyperbaric Oxygen Therapy, Alternative Therapies and autism Other: Dan Doctors, CDC, FDA, American Cancer Society, American Heart Association

  3. Chelation Therapy http://www.freewebs.com/eclectives/messtoons.htm

  4. What is Chelation Therapy? (key-lay-shun) • Process where harmful metal toxins are extracted from the body • Chelating agents injected into body (2 types of amino acids) • These agents bind to metals ions and secrete them out of the body http://research-chelation-therapy.com/about-autism-chelation-therapy/a-brief-history-of-chelation

  5. Chelation (key-LAY-shun) • History • First used in World War I as an antidote for arsenic based poisonous gas • After World War II it was used to treat Navy personnel • In the 1960’s the formula was modified and was the leading treatment for lead, arsenic, and mercury poisoning. • Many different chelating compounds have been discovered http://research-chelation-therapy.com/about-autism-chelation-therapy/a-brief-history-of-chelation

  6. What is Chelation Therapy Approved For? • American Academy of Child and Adolescent Psychiatry adopted guidelines for screening of lead poisoning and treatment • A individual shows (serious) elevated blood levels of lead in body through blood tests • Use Chelation therapy of Calcium EDTA http://www.aacap.org/cs/root/policy_statements/screening_children_for_lead_guidelines_for_children_and_adolescent_psychiatrists

  7. Freeman, S. K. (2007). The Complete Guide to Autism Treatment. Lynden, WA: SKF Books USA, Inc. Chelation Therapy “experts” claim this treatment works for everything from Clogged Arteries to sexual dysfunction

  8. Removes undesirable metals from the body Reverses the process of atherosclerosis Improves cerebrovascular arterial occlusion Improves memory, concentration, and vision Reversal of gangrene Restoration of memory Prevents and reverses problems of degenerative diseases Arthritis, scleroderma, and lupus Radiation toxicity Snake venom poisoning Digitalis intoxication Cardiac arthymia Freeman, S. K. (2007). The Complete Guide to Autism Treatment. Lynden, WA: SKF Books USA, Inc.

  9. Relationship to Autism The theory is that heavy metals have accumulated in the child’s system and detoxification of these heavy metals (mercury) will improve symptoms. One source of mercury is thought to be timerosol in vaccines Therefore, if the mercury is removed from the body, the symptoms will improve Mehl-Madrona, L., (2010). Detoxification for Heavy Metals as a Treatment for Autism. Retrieved October 10, 2010 from http://www.healing-arts.org/children/detoxification.htm

  10. Relationship to Autism Chelation Approved for use with individuals that tested through blood tests to have lead arsenic, or mercury poisoning . = Heavy Metal Mercury Mercury Vaccines Vaccines Autism Autism Chelation

  11. What do the “Expert” Say? • Blood Testing – tests present level in blood • Hair – measures excretion • Unprovoked urine –measures excretion (recent exposure) • Antibody Testing – glutathione (controls excretion) • Provocation Testing – measuring excretion Autism Research Institute . (2005). Treatment Options for Mercury/Metal Toxicity in Autism and Related Developmental Disabilities: Consensus Position Paper . Retrieved on 17 Oct 2010. http://www.autism.com/pdf/providers/heavymetals.pdf

  12. “Experts” - Testing Detoxification Testing – This proves that metals were in the system and that the detoxification agent removed the metals. Limitations • “One major limitation of these tests is that the reference range for the urine or stool generally involves a comparison to people who are NOT taking a detoxification agent, so that even a normal person would tend to have a high result. Thus, an experienced clinician needs to interpret the results carefully.” • “Another limitation is that low doses of the detoxification agents may fail to increase excretion significantly. It is not fully understood, but it appears that the first part of the dose may be neutralized by the body, so higher doses may be needed for provocation testing vs. long-term treatment.” • “One complexity of provocation tests is that the detoxification agent may preferentially bind to one metal first, so excretion of that metal may hide the presence of other metals. Mercury can be tightly bound to body tissue, and it may not be removed until significant amounts of other toxic metals have been removed.” Autism Research Institute . (2005). Treatment Options for Mercury/Metal Toxicity in Autism and Related Developmental Disabilities: Consensus Position Paper . Retrieved on 17 Oct 2010. http://www.autism.com/pdf/providers/heavymetals.pdf

  13. What Do “Experts” Say? http://www.evenbetternow.com/ (evenbettenow.com LLC) http://www.detoxamin.com/(World Health Products) http://www.maxamlabs.com/ (Maxam Nutraceutics) The use of these products are so simple that they can be done at home by untrained personnel!

  14. What Research Support Does Chelation Have? • World Health Products sites as support a study by Ted Rozema, MD – lead Poisoning CaEDTA Suppositories to Treat Elevated Blood Lead Levels in Children • Maxamlabs.com uses testimonials - http://www.maxamlabs.com/shopcontent.asp?type=Testimonial-Autism Almost Instant Gratification – p17 http://www.maxamlabs.com/shopcontent.asp?type=Testimonial-Autism-Behavior • http://www.healing-arts.org/children/detoxification.htm (Mehl-Madrona, M.D., Ph.D) CaEDTA Suppositories to Treat Elevated Blood Lead Levels in Children by Ted Rozema, MD http://www.maxamlabs.com/shopcontent.asp?type=Testimonial-Autism-Behavior http://www.maxamlabs.com/shopcontent.asp?type=Testimonial-Autism

  15. What Research Support Does Chelation Have? http://www.youtube.com/watch?v=hnsZ1zDb14E&feature=related

  16. Is Chelation Safe? According to the American Heart Association (2010), there are serious dangers associated with Chelation therapy. EDTA can cause the following: • kidney failure • bone marrow depression • shock • low blood pressure (hypotension) • convulsions • cardiac arrhythmias • respiratory arrest • death American Heart Association. (2010). Questions and Answers about Chelation Therapy. http://www.americanheart.org/presenter.jhtml?identifier=3000843 Retrieved 19 September 2010

  17. Oops! • The National Institutes of Health (NIH) through the National Center for Complementary and Alternative Medicine • funded a five-year study of Chelation therapy • 120 children with autism four to ten years old. • Half were to be given Chelation pills and the other half placebos. • The study was cancelled before it started • a study of rats with elevated lead levels that received Chelation therapy displayed improved learning, attention and arousal • they also had lasting cognitive impairment. • The cognitive impairment was even present in rats with normal lead levels that received the Chelation therapy. Pediatrics for Parents. Jan 2009 v25 i1 p5 (1).

  18. October Newswire On October 14, 2010, the FDA warned eight companies that are marketing Chelation products used for unapproved treatments and making false claims about the products is a violation federal law Chelation products, even when used under medical supervision, can cause serious harm, including dehydration, kidney failure, and death. US Department of Health and Human Services. (2010). FDA issues warnings to marketers of unapproved ‘Chelation’ products. Retrieved October 22, 2010 from http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm229320.htm

  19. Company’s World Health Products, LLC Hormonal Health, LLC and World Health Products, LLC Evenbetternow, LLC Maxam Nutraceutics/Maxam Laboratories Cardio Renew, Inc. Artery Health Institute, LLC Longevity Plus Dr. Rhonda Henry http://www.fda.gov/Drugs/ResourcesForYou/Consumers/BuyingUsingMedicineSafely/MedicationHealthFraud/ucm229313.htm

  20. Worthwhile Therapy? • According to Schechtman (2007), “children who received heavy metal Chelation failed to demonstrate improve neurodevelopment functions on follow-up.” • “Currently, there is no scientific data published in peer-reviewed journals to suggest that chelation Therapy is an effective treatment for individuals with autism” (Freeman, 183). • “The National Council Against Health Fraud believes that Chelation therapy is unethical and should be banned and that Chelation therapy of autistic children should be considered child abuse” (Freeman, 188). • The use of chelation therapy to treat autistic children is completely bogus (quackwatch.com) http://www.quackwatch.com/03HealthPromotion/immu/thimerosal.html Schechtman, M. A., (2007). Scientific Unsupported Therapies in the treatment of Young Children with Autism Spectrum Disorders. Psychiatric Annals 37 (9). 639-645 Freeman, S. K. (2007). The Complete Guide to Autism Treatment. Lynden, WA: SKF Books USA, Inc.

  21. Hyperbaric Oxygen Therapy

  22. What is Hyperbaric Oxygen Therapy (HBOT)? Hyperbaric oxygen therapy (HBOT) is done in a sealed chamber pressurized at 1 ½ to 3 times normal atmospheric pressure where the patient is breathing pure oxygen. American Cancer Society. (2010). Hyperbaric Oxygen therapy. Retrieved October 22, 2010 from http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/hyperbaric-oxygen-therapy

  23. History of Hyperbaric Oxygen Therapy? • Hyperbaric Oxygen Therapy (HBOT) has been used in medicine since the 1600’s. • Used clinically since 1800’s • Developed and tested after World War I • Used safely since 1930’s for decompression sickness (the bends and caisson disease) About.com (2010). The History of Hyperbaric Chambers and Hyperbaric Oxygen Therapy . Retrieved October 10, 2010 from http://inventors.about.com/library/inventors/blhyperbaric.htm

  24. History of Hyperbaric Oxygen Therapy (Continued) • In 1967, the Undersea and Hyperbaric Medical Society (UHMS) was founded. • The Hyperbaric Oxygen Committee was developed by the UHMS in 1976 to oversee the ethical practice of hyperbaric medicine About.com (2010). The History of Hyperbaric Chambers and Hyperbaric Oxygen Therapy . Retrieved October 10, 2010 from http://inventors.about.com/library/inventors/blhyperbaric.htm

  25. Approved uses for HBOT The bends is the common name given to decompression sickness or caisson disease. The bends occur when the pressure surrounding a person’s body drops quickly and air bubbles form in the blood stream. Most commonly, when a diver resurfaces too quickly. However, it also may occur when an unpressurized aircraft flies into lower pressure or when a miner resurfaces from a mine that has been pressurized to keep water out.

  26. Claims (Approved) FDA. (2001). Warning letter from US health and Human Services. Retrieved October 20, 2010 from http://www.fda.gov/downloads/ICECI/EnforcementActions/WarningLetters/2001/UCM069421.pdf • Air or Gas Embolism • Bone Grafts • Carbon Monoxide Poisoning and Smoke Inhalation • Carbon Monoxide Poisoning Complicated by Cyanide • Poisoning • Clostridial Myonecrosis (Gas Gangrene) • Crush Injury, Compartment Syndrome • Decompression Sickness (the "Bends") • Enhancement of Healing in Selected Problem Wounds • Exceptional Blood Loss (Anemia) • Necrotizing Soft Tissue Infections • Osteomyelitis (Refractory) • Radiation Tissue Damage (Osteoradionecrosis) • Skin Grafts and Flaps (Compromised) • Thermal Burns

  27. Claims (Not Approved) Acute Acoustic TraumaAcute and Chronic AnemiaAcute and Chronic Arterial InsufficiencyAIDSALS "lou Gehrig's Disease"Alzheimer's DiseaseAutistic disordersCandidas and Fungal InfectionsCerebral edemaCerebral Palsy, Epilepsy due to HypoxiaChemical Poisoning (e.g. Pesticide)Chronic Fatigue SyndromeClosed head injuryColitisCrohn’s Disease

  28. Compartmental SyndromeDiabetesFibromyalgiaFlesh Eating BacteriaFracture RepairGastric and Duodenal UlcersGuillain-Barre SyndromeHeadaches, ClusterHeart attack, Myocardial Ischemia    & Aid to Cardiac Surgery and RehabilitationHypoxic Birth DisordersInflammatory ArthritisLupusLyme DiseaseMacular DegenerationMigraineMultiple SclerosisMusculoskeletal InjuriesMycoplasma Hyperbaric O2ptions (2010). Discover Hyperbarics. Retrieved on October 24, 2010 from http://www.discoverhyperbaric.com/HBOT-approved-experimental-off-label-indications.html

  29. Musculoskeletal InjuriesMycoplasma Near drowningNear hangingNeurovascular compressionOsteoporosisParkinson’s diseasePeripheral nerve injury and neuropathies, demyelinationPeripheral Vascular DisordersPost surgical instabilityRehabilitative CareRetintisPigmentosaRSDRheumatoid ArthritisSacroiliac SyndromeScelodremaSilicone Induced DisordersSpinal Cord injurySpider bite Hyperbaric O2ptions (2010). Discover Hyperbarics. Retrieved on October 24, 2010 from http://www.discoverhyperbaric.com/HBOT-approved-experimental-off-label-indications.html

  30. Silicone Induced DisordersSpinal Cord injurySpider bite StrokeSudden deafness Surgery Healing, Pre and Post,  Reconstruction and Cosmetic SurgeryPost surgical soft tissue infectionsTOSVegetative comaWound Healing, Recurrent Ulcers and Infections Hyperbaric O2ptions (2010). Discover Hyperbarics. Retrieved on October 24, 2010 from http://www.discoverhyperbaric.com/HBOT-approved-experimental-off-label-indications.html

  31. Claims Hope Fine, South Florida Center for H.O.P.E. http://www.youtube.com/watch?v=cc8yFhFVehE Because the South Florida Center for H.O.P.E., is a free-standing facility, we have the opportunity to treat a spectrum of diagnosis including, but not limited to Autism, Cerebral Palsy, Stroke, Traumatic Brain Injury, PTSD, Multiple Sclerosis, Lyme Disease, Spinal Cord Injury, Near Drowning, Fibromyalgia, Migraines, Sports Injuries, Pre and Post Cosmetic Surgery and Cancer, as well as Non-healing Wounds, Radiation Injury, and Carbon Monoxide poisoning. South Florida Center for H.O.P.E. (2010). Retrieved September 29, 2010 from http://sfcenterforhope.com/

  32. Support Dr. Rossignol et al. conducted a few studies on children diagnosed with autism using hyperbaric oxygen therapy. Conclusions are promising. Important Limitations: • 8 of the 10 authors including Dr. Rossignol make money from hyperbaric oxygen therapy treatments. • Dr. Rossignol and two other investigators received research funding from Hyberbarics Association on a earlier study • Much of the study was evaluated on parental rating scales and this leaves room for bias. • The control group rated better than the treatment group in the areas of social withdrawal and hyperactivity Pauline Anderson (2009). Hyperbaric Therapy May Improve Autism Symptoms. Medscape Medical News

  33. Support http://www.californiahyperbarics.com/page_coming_soom.html http://www.youtube.com/watch?v=Xs3KuaoUe8w&feature=related http://www.youtube.com/watch?v=geBUrrLa3XI&feature=related http://www.drneubrander.com/dev/index.html

  34. Is HBOT Safe? • Otic Barotrauma (pain in the ears or sinuses) • Serous Otitis • Oxygen Toxicity • Visual Changes • Maturing or Ripening Cataracts • Cerebral Air Embolism and Pneumothorax • Risk of Fire. http://www.aurorahealthcare.org/services/hyperbaric/faq.asp

  35. Contraindications to Hyperbaric Oxygen Therapy Chronic sinusitis Congenital spherocytosis Emphysema with CO2 retention History of optic neuritis History of reconstructive ear surgery History of spontaneous pneumothorax History of thorax surgery Pulmonary lesions in routine X-ray or CT scan Seizure disorders Sickle cell anemia Uncontrolled high fever Upper respiratory infections Viral infections http://www.aurorahealthcare.org/services/hyperbaric/faq.asp

  36. Is HBOT Safe? Absolutely "NO" Blankets Books or Newspapers CD Players Cell Phones Crayons Lighters Matches Paper Products of Any Kind Pens Pencils Pocket Warmers redios Toys Electronic Games Laptop Computer "NO" Nylon Bras Contact Lenses Dentures Girdles Hair Accessories Hats or Caps Hearing Aides Jewelry (Watches, Rings, Bracelets, Etc) False Eyelashes Nail Polish (Must be dry at least 24 hours) Nylons (Hose or Pantyhose) Oral Retainers Support Braces (Unless approved by attending technician) Synthertics (I.E Rayon, Hylon, Etc) Wigs or Hair Pieces You Must Not Have Used: Deodorant Hair Gel or Mousse Hair Spray Lotions Make Up Ointments Perfume Petroleum Based Products/Vaseline Products Liniments Aftershave Products Salves www.sfcenterforhope.com

  37. Cost? http://www.hyperbaric4autism.com/ http://www.dive-hyperbarics.com/ http://www.hyperbaricsrx.com/hyperbaric-chamber-products.html

  38. Worthwhile Therapy? http://www.asatonline.org/helpdesk/research/hyperbaric.htm

  39. About.com (2010). The History of Hyperbaric Chambers and Hyperbaric Oxygen Therapy . Retrieved October 10, 2010 from http://inventors.about.com/library/inventors/blhyperbaric.htm American Cancer Society. (2010). Hyperbaric Oxygen therapy. Retrieved October 22, 2010 from http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/hyperbaric-oxygen-therapy American Heart Association. (2010). Questions and Answers about Chelation Therapy. http://www.americanheart.org/presenter.jhtml?identifier=3000843 Retrieved 19 September 2010 Autism Research Institute . (2005). Treatment Options for Mercury/Metal Toxicity in Autism and Related Developmental Disabilities: Consensus Position Paper . Retrieved on 17 Oct 2010. http://www.autism.com/pdf/providers/heavymetals.pdf Baker, Jeffrey P.. American Journal of Public Health, Feb2008, Vol. 98 Issue 2, p244-253, 10p; (AN 30103018) CDC (1991): Strategic Plan for the Elimination of Childhood Lead Poisioning. Centers for Disease Control, Department of Health and Human Services, Atlanta, GA. FDA. (2001). Warning letter from US health and Human Services. Retrieved October 20, 2010 from http://www.fda.gov/downloads/ICECI/EnforcementActions/WarningLetters/2001/UCM069421.pdf Freeman, S. K. (2007). The Complete Guide to Autism Treatment. Lynden, WA: SKF Books USA, Inc. Hyperbaric O2ptions (2010). Discover Hyperbarics. Retrieved on October 24, 2010 from http://www.discoverhyperbaric.com/HBOT-approved-experimental-off-label-indications.html Mayo Clinic. (2010). Autism treatment. Can Chelation therapy help? Retrieved October 16, 2010 from http://www.mayoclinic.com/health/autism-treatment/AN01488 Pardo CA, Eberhart CG. The neurobiology of autism. Brain Pathology 2007: 17(4): 434-47.

  40. Rossignol, D et al. “The effects of hyperbaric oxygen therapy on oxidative stress, inflammation, and symptoms in children with autism: an open-label pilot study.” BMC Pediatrics 2007, 7:36. Rossignol DA, et al. Hyperbaric treatment for children with autism: a multicenter, randomized, double-blind, controlled trial. BMC Pediatr.2009 Mar 13;9(1):21. Rossignol, D., “Hyperbaric oxygen therapy may improve symptoms in autistic children.” Med Hypotheses. 2006:67 (2) 216-28. Quackwatch, http://www.quackwatch.com/03HealthPromotion/immu/thimerosal.html http://www.aacap.org/cs/root/policy_statements/screening_children_for_lead_guidelines_for_children_and_adolescent_psychiatrists http://research-chelation-therapy.com/about-autism-chelation-therapy/a-brief-history-of-chelation http://www.youtube.com/watch?v=cc8yFhFVehE http://www.hyperbaric4autism.com/ http://www.dive-hyperbarics.com/ http://www.hyperbaricsrx.com/hyperbaric-chamber-products.html http://www.drneubrander.com/dev/index.html http://www.youtube.com/watch?v=cc8yFhFVehE http://www.youtube.com/watch?v=hnsZ1zDb14E&feature=related http://www.evenbetternow.com/ http://www.detoxamin.com/ http://www.maxamlabs.com/

  41. Any Questions? Thank you!!

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