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Integration of GO and PO Ontologies for Enhanced Biological Process and Cellular Component Definitions

This project focuses on integrating Gene Ontology (GO) and Plant Ontology (PO) logical definitions to improve biological process and cellular component annotations. Key examples include the definitions surrounding flower development and root hair tips, which demonstrate how plant development is categorized. The integration aims to streamline GO term definitions using tools like TermGenie for better automatic placement within GO hierarchy, alongside reflecting updates in the Plant Ontology. The current status shows 152 logical definitions identified for future enhancement.

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Integration of GO and PO Ontologies for Enhanced Biological Process and Cellular Component Definitions

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  1. GO/PO interconnections Tanya Berardini GO Ontology Developer TAIR Annotator

  2. GO terms with PO references • Biological Process: esp. Developmental Process • Ex. flower development • Cellular Component • Ex. root hair tip

  3. Protégé 4.3

  4. GO logical definitions using PO • Biological Process [Term] id: GO:0009908 ! flower development subset: goslim_plant intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 PO:0009046 ! results in development of flower • Cellular Component [Term] id: GO:0035619 ! root hair tip intersection_of: GO:0044463 ! cellprojection part intersection_of: BFO:0000050 PO:0025164 ! part_of root epidermalcell

  5. Current Status • 152 logical definitions in file that is separate from the main GO

  6. Future Plans • Integrate GO/PO logical definitions into main GO file • Add a new TermGenie template/s for PO-related GO terms • go.termgenie.org • TG templates will facilitate automatic placement of such terms in the GO hierarchy based on existing related GO terms and the current PO structure • Changes in the PO will be reflected by changes in the related GO terms, if such changes are necessary

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