Ch 36 Musculoskeletal System . AP lecture. Three vertebrate muscles. Skeletal A.k.a striated Voluntary movements . Cardiac Involuntary Beating of the heart Appears striated because of myosin and actin Smaller than skeletal Cells attached by gap junctions . Smooth InvoluntaryBy Anita
Thick Filament: Myosin. Thin Filament: Actin. Movie of muscle contraction http://www.octc.kctcs.edu/gcaplan/anat/Notes/API%20Notes%20J%20%20Muscle%20Contraction.htm.By baruch
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Actin Filament Assembly, Growth, Branching, Capping and Disassembly are Controlled by Actin Binding Proteins. Actin polymerization is induced by Arp 2/3 protein complex at the surface of Listeria monocytogenes Matthew D. Welch et al.
actin. troponin. actin. tropomyosin. troponin. actin. tropomyosin. troponin. actin. myosin binding site. tropomyosin. troponin. actin. Ca 2+. Ca 2+. Ca 2+. Ca 2+. Ca 2+. Ca 2+. Ca 2+. Ca 2+. Calcium ions are released from the sarcolemma after stimulation from the T system.
A. PD PDD NPC PD PDD NPC PD PDD NPC. DJ-1 Complex. Native. Total DJ-1. Denative. Actin. B. Total DJ-1/Actin. DJ-1 HMW Complex/Actin.
+ arp2/3 complex + profilin 1.5 µM. actin. + arp2/3 complex. Actin + Arp2/3 complex + formin Cdc12 + profilin. Actin + formin Cdc12. Actin + formin Cdc12 + profilin. Actin + Arp2/3 complex + formin Cdc12.
G-actin F-actin. Regulation of actin filament dynamics in vivo Fig. 16-52, Alberts. Drugs that stabilize actin filaments, e.g. phalloidins (bind to sides of f-actin). Drugs that destabilize actin filaments e.g. cytochalasins Cytochalasin D (binds +end of f-actin)
Supplementary Figure S1. Lee et al. PEA-15. Actin. Hey. 2774. RMG-1. KOC-7c. OVTOKO. OVCA420. OVCA432. SKOV3.ip1.
A. VHA-B. B. VHA-B. NHX1. NHX1. CLC1. CLC1. CatA. CatA. Actin. WT WT. Actin. Control Stress. WT S1 S4.
Vehicle. TCDD. (+). MW. AhR. Actin. Vehicle. TCDD. (+). MW. AhR. Actin. (A). Vehicle. TCDD. (+). MW. Cyp1b1. (B). Cyp1a1. Actin.
Actin. Highly conserved Most abundant intracellular protein (in eukaryotes). Fig 18-4. Structure of actin. Polarity of molecule ‘-” and ‘+’ ends T form and D form G- actin vs F- actin. Fig 18-2. Structure of actin. View from ‘-’end. Fig 18-2. Bundles and Networks.