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Schizophrenia

Schizophrenia

Schizophrenia. Chapter 10. Psychopathology. Sooner or later, half the population suffers a serious run-in Reactive or endogenous Very expensive Historically, known to run in families. Schizophrenia. Lifetime risk ~1% Long-term thought disorder Cognitive, emotional, motivational

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519 views • 40 slides
Single Nucleotide Polymorphism Copy Number Variations and SNP Array

Single Nucleotide Polymorphism Copy Number Variations and SNP Array

Single Nucleotide Polymorphism Copy Number Variations and SNP Array. Xiaole Shirley Liu and Jun Liu. Outline. Definition and motivation SNP distribution and characteristics Allele frequency, LD, population stratification SNP discovery (unknown) and genotyping (known) CNV detection.

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1.62k views • 28 slides
Association Tests for Rare Variants Using Sequence Data

Association Tests for Rare Variants Using Sequence Data

Association Tests for Rare Variants Using Sequence Data. Guimin Gao , Wenan Chen, & Xi Gao Department of Biostatistics, VCU. Introduction to Association tests: two hypotheses. Common variant-common disease Common variant: Minor allele frequencies (MAF) >= 5%

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381 views • 27 slides
PolyPhen and SIFT: Tools for predicting functional effects of SNPs

PolyPhen and SIFT: Tools for predicting functional effects of SNPs

PolyPhen and SIFT: Tools for predicting functional effects of SNPs. Epi 244 Spring 2009 Sam S. Oh. Human genome variation. 3.2 billion base pairs (bp) 99.9% similarity across individuals 3.2 million bp dissimilar ~11 million SNPs Coding vs. non-coding (intron and intergenic regions)

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349 views • 26 slides
Facilitating analysis of genomic variation in Olympia oysters

Facilitating analysis of genomic variation in Olympia oysters

Facilitating analysis of genomic variation in Olympia oysters. Bioinformatics, FISH546 Mackenzie Gavery 3/14/13. GOALS. U tilize existing genomic resources (transcriptome) for RAD- Seq design Generate useful generic feature files ( gff ) to facilitate functional annotation of SNPs

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201 views • 8 slides

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