Strand transfer - PowerPoint PPT Presentation

AIDS2012 TUAA0301

AIDS2012 TUAA0301. Pre-clinical Evaluation of HIV Replication Inhibitors that Target the HIV Integrase -LEDGF/p75 Interaction Frauke Christ , Chris Pickford, Jonas Demeulemeester, Stephen Shaw, Belete Desiemmie, Caroline Smith-Burchnell, Scott Butler, Mike Westby, Zeger Debyser

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Mu DNA

Mu DNA. &quot;. 5’. 5’. &quot;. donor cleavage . 5’. -OH. HO-. 5’. cleaved intermediate (above) + target DNA (below). 5’. strand transfer reaction. 5’. -OH. 5’. -OH. strand transfer intermediate. 5’. 5’. replication. 5’. 5’. 5’. cointegrate.

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166 views • 1 slides

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