Spirobenzylisoquinoline - PowerPoint PPT Presentation

螺旋基異類似物之合成與立體化學之研究

螺旋基異類似物之合成與立體化學之研究. 中文摘要螺旋基異類似物之合成與立體化學之研究 JKL 1067 (2,3-methylenedioxy-9,10-dimethoxyspirobenzylisoquino line) (4) 是一個合成的螺旋基異，具有增加心收縮力及減緩自發性心跳速率之抗心律不整藥物。在本實驗室以往所合成出的十五種螺旋基異類似物中，發現三種類似物之藥理活性與 JKL 1067 相當或更強，依據藥效較佳化合物之構造特徵，我們以化學合

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