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Single-gene Disorders. Classification of genetic disorders. Single-gene disorders (2%) Chromosome disorders ( < 1%) Multifactorial disorders (60%). Pedigree. Pedigree. Pedigree. Pedigree symbols. Types of Mutation. Gene Mutation base-pair mutation. Nucleotide Substitutions
Single Gene Traits: Earlobes. phenotype : a product/trait resulting from a gene. Alleles. alternative forms of a gene we inherit 2 alleles of every gene (1 from mom, 1 from dad) . Alleles for Earlobe Shape:. Attached: recessive, f. Free: dominant, F.
CHAPTER 2 Single-Gene Inheritance. 2.2 Single-gene inheritance patterns 2.3 The chromosomal basis of single-gene inheritance patterns 2.1 Genes and chromosomes 2.5 Sex-linked single-gene inheritance patterns 2.6 Human pedigree analysis. CHAPTER OUTLINE.
Lecture 3: Single gene inheritance. Mutations. Haploinsufficient phenotpyes. Pax 6 mutation. normal. AC absent. Olfactory bulb hypoplasia. Pax 6 mutation phenotype: aniridia , hyposmia. Single gene inheritance in haploids: budding yeast. ascus. Products of meiosis in yeast.
Single Gene Inheritance Chapter 2. Gene are located on chromosomes. - the two members of an homologous pair carry alleles for the same genes and, therefore, affect the same traits. The stuff that makes up chromosomes. Chromatin condenses into chromosomes at cell division.
Single gene effects on behavior. How do gene products affect behavior? What methods are used to study single-gene effects? Segregation analysis Gene mapping Differences in mRNA between individuals or cell types correlates with behavior Genetic engineering.
Patterns of Single-Gene Inheritance. Lecture 3. Autosomal Dominant Inheritance. More than half of all mendelian disorders are inherited as AD traits.
Gene Mapping Gene Therapy. Review Question 2: Crossing Over. Can someone show me on the SMARTboard what crossing over is and when it occurs?. Before crossing over. After crossing over. Gametes. Gene Linkage and Crossing Over. Think about a cross between parents GGYY and ggyy.