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Differentspectrophotometric methods manipulating ratio spectra for simultaneous determination of salbutamol and bromhexi

Differentspectrophotometric methods manipulating ratio spectra for simultaneous determination of salbutamol and bromhexi

Four simple, specific, accurate and precise spectrophotometric methods manipulating ratio spectra were developed and validated for simultaneous determination of Salbutamol (SL) and Bromhexine (BH) namely; dual wavelength, ratio difference, ratio derivative, mean centering. The proposed spectrophotometric procedures do not require any preliminary separation step. The accuracy, precision and linearity ranges of the proposed methods were determined. The four methods were applied for the determination of the cited drugs in tablets and the obtained results were statistically compared with a reported spectrophotometric method. The comparison showed that there is no significant difference between the proposed methods and the reported method regarding both accuracy and precision.

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146 views • 14 slides
Quantitative analysis of cefadroxil in presence of its degradation product by various spectrophotometric techniques

Quantitative analysis of cefadroxil in presence of its degradation product by various spectrophotometric techniques

Simple,Accurate,selective and sensitive spectrophotometric methods have been developed and validated for determination of cefadroxil in presence of its alkaline degradation product without preliminary separation. These methods include area under the curve method (AUC), Q-Analysis method (QA), ratio derivative method, Ratio difference method and Mean centering method. These methods were validated and successfully applied to the determination of Duricefu00c6 500mg capsule. The obtained results were statistically compared with those of the reported method by applying ttest and F-test at 95% confidence level and no significant difference was observed regarding accuracy and precision.

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114 views • 11 slides
Quantitative determination of citalopram hydrobromide by spectro- photometry and chemometry in presence of its degradati

Quantitative determination of citalopram hydrobromide by spectro- photometry and chemometry in presence of its degradati

Simple, accurate, sensitive and validated UV stability-indicating spectro- photometric and chemometric methods were developed for determination of Citalopram Hydrobromide (CT) in presence of its alkaline, oxidative degradation products and in its pharmaceutical preparation. Method (A) is a successive derivative ratio spectrophotometricone, which depends on the successive derivative ofratio spectra in two steps and measuring Citalopram Hydrobromide at 277nm and 293nm. Method (B) is mean centering of ratio spectra which dependson using the mean centered ratio spectra in two successive steps and measuring the mean centeredvalues of the second ratio spectra at 237nm and method (C) used two chemometric techniques ; principal component regression(PCR) and partial least-squares (PLS). The proposed methods werechecked using laboratory-prepared mixtures and were successfully applied for the analysis of pharmaceuticalformulation containing Citalopram Hydrobromide. The proposed methods were vali- dated according to the ICH guidelines. The obtained results were statisti- cally compared with those obtained froma compendial HPLC method,showing no significant difference with respect to accuracy and precision.

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109 views • 10 slides

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