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New perspectives in the therapy with PPAR- ? agonists .

New perspectives in the therapy with PPAR- ? agonists .

XIII International Symposium Heart Failure & Co. New perspectives in the therapy with PPAR- ? agonists. Carlo Maria Rotella, Ilaria Dicembrini. Napoli, 12-13 aprile 2013. Properties of PPAR- ?. PPAR- ? ligands. Adverse events associated with PPAR- ? agonists.

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345 views • 16 slides
QSAR studies on bisaryl substituted thiazoles and oxazoles as PPARδ agonists

QSAR studies on bisaryl substituted thiazoles and oxazoles as PPARδ agonists

A linear quantitative structure-activity relationship (QSAR) model is presented for modeling and predicting the agonistic activity of PPARδ receptor. The model was produced by using the multiple linear regression (MLR) technique on a compound database that consists of newly discovered bisaryl substituted thiazoles and oxazoles. The major conclusion of this study is that molecular weight, wiener index, andrews affinity and polar surface area affect significantly the agonistic activity of PPARδ receptor by bisaryl substituted thiazoles and oxazoles. The selected QSAR descriptors serve as a primary guidance for the design of novel and selective PPARδ receptor agonists.

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122 views • 10 slides
PPAR- ? is a modulator of the inflammatory response

PPAR- ? is a modulator of the inflammatory response

PPAR- ? is a modulator of the inflammatory response acting at the level of the vascular wall and the liver. Alberto Zambon, et al. ATVB 2006; 26: 977-986. Interaction of PPAR-? at several levels of the inflammatory signaling pathway. Alberto Zambon, et al. ATVB 2006; 26: 977-986.

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209 views • 5 slides

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