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The use of PBPK modeling to reduce uncertainty in risk assessment: Example of manganese

The use of PBPK modeling to reduce uncertainty in risk assessment: Example of manganese

The use of PBPK modeling to reduce uncertainty in risk assessment: Example of manganese. Harvey Clewell, PhD, DABT Director, Center for Human Health Assessment The Hamner Institutes for Health Sciences. Manganese: An Essential Poison.

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761 views • 61 slides
The use of PBPK modeling to reduce uncertainty in risk assessment: Example of manganese

The use of PBPK modeling to reduce uncertainty in risk assessment: Example of manganese

The use of PBPK modeling to reduce uncertainty in risk assessment: Example of manganese. Harvey Clewell, PhD, DABT Director, Center for Human Health Assessment The Hamner Institutes for Health Sciences. Manganese: An Essential Poison.

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622 views • 61 slides
Elaina M. Kenyon Hisham A. El-Masri Rory B. Conolly U.S. EPA, ORD

Elaina M. Kenyon Hisham A. El-Masri Rory B. Conolly U.S. EPA, ORD

Integration of Pharmacokinetic (PK) and Pharmacodynamic (PD) Modeling of Arsenic to Inform the Risk Assessment Process. Elaina M. Kenyon Hisham A. El-Masri Rory B. Conolly U.S. EPA, ORD. Disclaimer !.

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605 views • 60 slides
Physiological Modeling of the Dermal Absorption of Octamethylcyclotetrasiloxane (D4)

Physiological Modeling of the Dermal Absorption of Octamethylcyclotetrasiloxane (D4)

Physiological Modeling of the Dermal Absorption of Octamethylcyclotetrasiloxane (D4). 1 Quantitative and Computational Toxicology Group, The Center for Environmental Toxicology and Technology, Colorado State University, Fort Collins, Colorado 80523

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204 views • 20 slides
R E S E A R C H T R I A N G L E P A R K , N O R T H C A R O L I N A

R E S E A R C H T R I A N G L E P A R K , N O R T H C A R O L I N A

R E S E A R C H T R I A N G L E P A R K , N O R T H C A R O L I N A.

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247 views • 18 slides
R E S E A R C H T R I A N G L E P A R K , N O R T H C A R O L I N A

R E S E A R C H T R I A N G L E P A R K , N O R T H C A R O L I N A

R E S E A R C H T R I A N G L E P A R K , N O R T H C A R O L I N A.

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184 views • 18 slides
Time after induction (h)

Time after induction (h)

7. 6. 5. 4. PBPK model. Blood propofol concentration ( m g/ml). 3. 2. Integrative model. 1. 0. 8. 0. 2. 4. 6. 10. Time after induction (h).

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127 views • 1 slides

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