'Pathogenicity islands' presentation slideshows

Welcome to Introduction to Computational Genomics for Infectious Disease

Welcome to Introduction to Computational Genomics for Infectious Disease. Course Instructors. Instructor James Galagan Teaching Assistants Lab Instructors. Schedule and Logistics. Lectures Labs. Tues/Thurs 11-12:30 Harvard School of Public Health: FXB-301

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Pathogenomics Using bioinformatics to focus studies of bacterial pathogenicity

Pathogenomics Using bioinformatics to focus studies of bacterial pathogenicity. Explosion of data 23 of the 34 publicly available microbial genome sequences are for bacterial pathogens Approximately 21,000 pathogen genes with no known function!

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TOXIGENESIS

TOXIGENESIS. Two types of bacterial toxins. lipopolysaccharides , which are associated with the cell walls of Gram-negative bacteria. proteins , which may be released into the extracellular environment of pathogenic bacteria. Endotoxins. Endotoxins are: Toxic to most mammals.

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The Challenges of the Mobilome

The Challenges of the Mobilome. Alicia Vachon MMIC 7050 October 1 st , 2019. Summary. What is a mobilome ? A nalysis of the mobilome Challenges in analysis Importance of the mobilome in analysis: Microbial pathogenesis understanding Epidemiological context Take home messages.

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IslandPath: A computational aid for identifying genomic islands

Whole Genome (predicted) ORF Display:. Genome ORFs are displayed to allow interesting regions (rich in mobility genes, abnormal %G+C, close to structural RNAs) to be viewed in a genome context. E.g. H. Pylori 26695 Genome. %G+C Analysis General Observations:.

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Computational tools to aid identification of potential horizontally transferred genes involved in pathogenicity

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