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P53 Signaling Pathway

p53 has many mechanisms of anticancer function and plays a role in apoptosis, monitor DNA replication, cell division, and inhibition of angiogenesis. As an anti-cancer promotion agent, it can activate DNA repair proteins when DNA has sustained damage, induce growth arrest by holding the cell cycle at the G1/S regulation point on DNA damage recognition, or initiate apoptosis if DNA damage proves to be irreparable.

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p53 signaling pathway

p53 is a tumor suppressor protein encoded in humans by the TP53 gene. It had been identified in the 1970s as a binding partner for the SV40 tumor virus oncoprotein large T antigen and an important target for tumor-igenic processes induced by DNA tumor viruses, research in the late 1980s and 1990s validated p53 as a tumor suppressor gene, as p53 mutations were found in up to 50% of human cancers. http://www.creative-diagnostics.com/p53-signaling-pathway.html

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P53 Signaling Pathway

p53 signaling pathway