Neutral molecules - PowerPoint PPT Presentation

HPLC Analysis of Ionic Compounds

HPLC Analysis of Ionic Compounds. Nicholas H. Snow Seton Hall University. HPLC of Ionic Compounds. Ion Suppression Ion Exchange Chromatography (IEX or IEC) Ion Pair Chromatography (IPC). Weak Acid Equilibrium. LeChatelier Principle. DO NOT chromatograph at pH = pKa !!. Ion Suppression.

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ESM technology: enhancing drug performance

ESM technology: enhancing drug performance. Neutral molecules pass freely through cell. Pharmacokinetics limited by clearance from plasma. Intracellular target. “Parent” molecule. ESM technology: enhancing drug performance. Linking motif to parent creates novel IP.

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