'Nature reviews drug discovery' presentation slideshows

Pulmonary hypertension in LV dysfunction

Pulmonary hypertension in LV dysfunction . Dr Angela Worthington April 5 th 2011. Overview. Normal pulmonary physiology Pathophysiology Clinical research Therapeutic trials. The Right Ventricle. RV is thin walled and distensible

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NSAIDs

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Adaptive Clinical Trials: A New Paradigm in Drug Development

Adaptive Clinical Trials: A New Paradigm in Drug Development. Donald A. Berry dberry@mdanderson.org. Financial Disclosure. Part owner Berry Consultants, LLC. Designs adaptive trials for medical device and pharmaceutical companies. Outline.

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Tools of the Trade

Tools of the Trade. Laboratory Notebook. Objectives of a Good Lab Notebook State what was done State what was observed Be easily understandable to someone else. Tools of the Trade. Laboratory Notebook Bad Laboratory Practice ( A Recent Legal Case)

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Protein Sequence Analysis - Overview

Protein Sequence Analysis - Overview. Raja Mazumder Scientific Coordinator, PIR Research Assistant Professor, Department of Biochemistry and Molecular Biology Georgetown University Medical Center. NIH Proteomics Workshop 2006. Overview.

490 views • 35 slides

Protein Sequence Analysis - Overview

Protein Sequence Analysis - Overview. Raja Mazumder Senior Protein Scientist, PIR Assistant Professor, Department of Biochemistry and Molecular Biology Georgetown University Medical Center. NIH Proteomics Workshop 2004. Overview.

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Regulatory issues in Latin America

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corporate presentation

corporate presentation. october 2011. disclaimer.

415 views • 29 slides

Antibody and prodrug therapy of cancer

Antibody and prodrug therapy of cancer. Steve Roffler. Institute of Biomedical Sciences. Academia Sinica. Overview. Cancer drug therapeutic index Antibody targeted prodrug activation 9ACG - new glucuronide prodrug. Surface expression of proteins. scFv activation of T cells.

743 views • 28 slides

Influenza

Influenza . Peggy Beeley, MD Best Practice 1/15/14. Outline. Current Outbreak Brief review of Influenza structure & subtypes Transmission and Prevention Available Testing Treatment Prophylaxis. Signs & Symptoms. C omplications. Fever Cough Sore throat Coryza or nasal congesting

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Introduction to Antibody Drug Conjugates (ADC) John Milne PhD, NIBRT 20 th June 2014

Introduction to Antibody Drug Conjugates (ADC) John Milne PhD, NIBRT 20 th June 2014. Paul Ehrlich (1854-1915). Ehrlich reasoned that if a compound could be made that selectively targeted a disease-causing organism, then a toxin for

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TPP: Are Data Exclusivity Provisions Reasonable?

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Paulina Nguyen HHMI Recipient Mentor: Dr. Ganesh Cherala Lab: OSU-College of Pharmacy

Effect of Perinatal Low Protein Diet on the Expression of Renal Organic Cation Transporters in Adult Rats. Paulina Nguyen HHMI Recipient Mentor: Dr. Ganesh Cherala Lab: OSU-College of Pharmacy. Low Birth Weight ( LBW ).

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Aerobic Glycolysis & Cancer

Aerobic Glycolysis & Cancer. Gemma Leung, Imninder Gill, David Liu, Cheryl Wong. PHM142 Fall 2012 Instructor: Dr. Jeffrey Henderson. Glycolysis. Oxidative phosphorylation. ATP Yield. What is the Warburg Effect?.

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Crystallinity in Polymers

Crystallinity in Polymers. Brandon Rawlings February 12, 2009. Crystalline Structures. Single Crystals. Polymer Spherulites. Sharmistha Datta & David J. W. Grant, Nature Reviews Drug Discovery 3, 42-57 (January 2004). Physical State Transitions. Amorphous Polymer. Crystalline Polymer.

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Designing Strategies for Neglected Disease Research

Designing Strategies for Neglected Disease Research. Lecture 1A Amy Kapczynski UC Berkeley Law. From MSF Campaign for Access to Essential Medicines, AccessNews (No. 18, Jan 2009). Female Life Expectancy at Birth (2006). Japan - 86. Sierra Leone - 42.

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GTX: An opportunity not to be missed?

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Prodrugs

Prodrugs. Sometimes drugs are designed to make use of metabolic processes in order to generate their active form. This is done in order to improve some selected property of the molecule, such as water solubility or ability to cross a membrane, temporarily.

565 views • 14 slides