Ch 9:T cell receptor. Where we’re going. Structure of the TCR- alpha and beta chains ( αβ ) The γδ Tcells- know a bit about them The CD3 components and signal transduction-cover much, responsible for just a few concepts. Alloreactivity. Review of TCR’s.By cicely
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MHC Class I. *. Ends are closed, and 2 -3 pockets at each end. Important Points. Closed ends of class I cleft limit peptide size Anchor residues of peptide fit into class I pockets Peptides bulge or kink Peptide binding motifs predict T cell epitopes
Cytotoxic T cell. Helper T cell. T H. Tc. T cell receptor. Fragments of foreign protein. Class II MHC protein. Class I MHC protein. Fragments of foreign protein. Antigen presenting cell. infected target cell. Helper T cells: • Express CD4 molecule on the cell surface.
MHC. Histocompatibility Ags 1-Minor Histocompatibility Complex HLA 2-Major Histocompatiblity Complex H-2. Major Histocompatibility Complex (MHC). What is MHC? HLA H-2 Minor histocompatibility antigens.
MHC. By. Dr. Emad AbdElhameed Morad. Lecturer of Medical Microbiology and Immunology. Transplantation is grafting tissues from one individual to another or from one place to another in the same individual. The main problem in organ transplantation is the occurrence of graft rejection .
MHC . A Review. MHC. Originally discovered in the 1930s by Peter Gorer ( gorer , 1936) MHC was genetically defined by George Snell (1948) Human Leukocyte Antigen (HLA) was sequences by Betck et al. in 1999
MHC. March 24, 2009 11:00-12:00. MHC CLASS I AND CLASS II ARE LINKED. MHC class I, II, and III are located in a cluster. The cluster is called HLA for human leukocyte antigen. MHC GENES ARE POLYGENIC. There are 3 “classical” class I genes: A,B,C. There are multiple class II genes.
MHC. Az MHC polimorfizmusa (Major histocompatibility complex). Polimorf gén--- több változat (allél) előfordulása az adott génszakaszon (lokuszon) Az MHC a legpolimorfabb fehérjénk, a legtöbb féle változatban jelenik meg a populációban.