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Ch 9:T cell receptor

Ch 9:T cell receptor

Ch 9:T cell receptor. Where we’re going. Structure of the TCR- alpha and beta chains ( αβ ) The γδ Tcells- know a bit about them The CD3 components and signal transduction-cover much, responsible for just a few concepts. Alloreactivity. Review of TCR’s.

By cicely
(149 views)


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MHC-I

MHC-I

1. 2. H+E. H+E. 3. 4. MHC-I. H+E.

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MHC Class I

MHC Class I

MHC Class I. *. Ends are closed, and 2 -3 pockets at each end. Important Points. Closed ends of class I cleft limit peptide size Anchor residues of peptide fit into class I pockets Peptides bulge or kink Peptide binding motifs predict T cell epitopes

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Class I MHC protein

Class I MHC protein

Cytotoxic T cell. Helper T cell. T H. Tc. T cell receptor. Fragments of foreign protein. Class II MHC protein. Class I MHC protein. Fragments of foreign protein. Antigen presenting cell. infected target cell. Helper T cells: • Express CD4 molecule on the cell surface.

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MHC

MHC

MHC. Histocompatibility Ags 1-Minor Histocompatibility Complex HLA 2-Major Histocompatiblity Complex H-2. Major Histocompatibility Complex (MHC). What is MHC? HLA H-2 Minor histocompatibility antigens.

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MHC

MHC

MHC. By. Dr. Emad AbdElhameed Morad. Lecturer of Medical Microbiology and Immunology. Transplantation is grafting tissues from one individual to another or from one place to another in the same individual. The main problem in organ transplantation is the occurrence of graft rejection .

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MHC

MHC

MHC . A Review. MHC. Originally discovered in the 1930s by Peter Gorer ( gorer , 1936) MHC was genetically defined by George Snell (1948) Human Leukocyte Antigen (HLA) was sequences by Betck et al. in 1999

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MHC

MHC

a. GM. DM1. DM3. DM5. DM7. b. MHC +DAPI. MHC. GM. DM4.

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MHC

MHC

MHC. March 24, 2009 11:00-12:00. MHC CLASS I AND CLASS II ARE LINKED. MHC class I, II, and III are located in a cluster. The cluster is called HLA for human leukocyte antigen. MHC GENES ARE POLYGENIC. There are 3 “classical” class I genes: A,B,C. There are multiple class II genes.

By ljoyner (0 views)

MHC

MHC

MHC. Az MHC polimorfizmusa (Major histocompatibility complex). Polimorf gén--- több változat (allél) előfordulása az adott génszakaszon (lokuszon) Az MHC a legpolimorfabb fehérjénk, a legtöbb féle változatban jelenik meg a populációban.

By ann-hopkins (130 views)