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The Distribution of Fitness Effects of Mutations in Humans and Flies

The Distribution of Fitness Effects of Mutations in Humans and Flies. Adam Eyre-Walker (University of Sussex). -ve. +ve. 0. Types of Mutation. Deleterious Neutral Advantageous. Deleterious Mutations. Mutation accumulation and Mutagenesis expts. d n /d s in primates. <30%. <10%.

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Low frequency variants - PowerPoint PPT Presentation

The Distribution of Fitness Effects of Mutations in Humans and Flies