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Changing the Test Statistic After an Interim Analysis

Changing the Test Statistic After an Interim Analysis. John Lawrence, DBI. I. Motivation II. Outline of procedure III. Simulation results. Outline. What is required to show efficacy?. 2-arm study to show that a drug is superior to placebo on survival or time to event

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Logrank statistic - PowerPoint PPT Presentation

Changing the Test Statistic After an Interim Analysis