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Considerations for Analyzing Targeted NGS Data Introduction

Considerations for Analyzing Targeted NGS Data Introduction

Considerations for Analyzing Targeted NGS Data Introduction. Tim Hague , CTO. Introduction. Many mapping, alignment and variant calling algorithms Most of these have been developed for whole genome sequencing and to some extent population genetic studi es. Premise.

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407 views • 31 slides
Introduction to Bioinformatics

Introduction to Bioinformatics

Introduction to Bioinformatics. Substitution Patterns. Substitution Patterns. Substitutions at the level of DNA are accumulated Analyses of number and nature of substitutions are important to Molecular evolution study Recognition of functionally important genes (due to natural selection).

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826 views • 24 slides
Chapter 3 Substitution Patterns

Chapter 3 Substitution Patterns

Chapter 3 Substitution Patterns. Presented by: Adrian Padilla. Overview. Patterns of Substitutions within Genes Mutation rates Functional constraint Synonymous vs. Nonsynonymous substitutions Indels and pseudogenes Substitutions vs. mutations Fixation. Overview.

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223 views • 21 slides
WHI Imputation update

WHI Imputation update

WHI Imputation update. Shuo Jiao. Status. WHIMS imputation is done 5,696 samples; 584,279 genotyped SNPs that overlaps with reference panel (Omni Express) Imputed to 28,097,484 SNPs; 2,760,266 Indels If we used the same R2 cutoff as implemented in GECCO 1KGP imputation

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256 views • 3 slides
low divergence or/and Low rate of indels

low divergence or/and Low rate of indels

low divergence or/and Low rate of indels. high divergence or/and high rate of indels.

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84 views • 1 slides

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