'Immunogenicity' presentation slideshows

Immunogenicity - PowerPoint PPT Presentation

Fundamentals of Acquired Immunity

Fundamentals of Acquired Immunity

Fundamentals of Acquired Immunity. I. Definitions. Immunology – the study of all aspects of host defense against infection and of adverse consequences of immune response Immunity – the state of protection fro infectious diseases utilizing both innate and acquired mechanisms.

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1.46k views • 96 slides
Chapter 4 Antigen

Chapter 4 Antigen

Chapter 4 Antigen. Definitions of antigen Antigen : non-self substances which can combine with TCR or BCR or Ab and have the potential of inducing immune response . Antigen: Tolerogen: an antigen that induces immunological tolerance

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1.14k views • 55 slides
Meningococcal A,C,Y,W135 Conjugate Vaccine (Menactra TM )

Meningococcal A,C,Y,W135 Conjugate Vaccine (Menactra TM )

Aventis Pasteur, Inc. Meningococcal A,C,Y,W135 Conjugate Vaccine (Menactra TM ). Lucia H. Lee CBER, FDA. Vaccines and Related Biological Products Advisory Committee Meeting September 22, 2004. Outline. Proposed Basis for Licensure: 11-55 years old Clinical Studies

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838 views • 48 slides
H5N1 Pediatric Experience

H5N1 Pediatric Experience

H5N1 Pediatric Experience. A Randomized, Double-blinded, Placebo-controlled, Phase I/II, Study of the Safety, Reactogenicity, and Immunogenicity of Intramuscular Inactivated Influenza A/H5N1 Vaccine In Healthy Children Aged 2 Years Through 9 Years (DMID 04-077)

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610 views • 43 slides
Combined paediatric vaccines for national immunization programmes

Combined paediatric vaccines for national immunization programmes

Combined paediatric vaccines for national immunization programmes. Francis E. André Vice-President and senior Medical Director GlaxoSmithKline , Rixensart, Belgium. Current shifts in pediatric immunization. Replacement of DTPw by DTPa Introduction of universal hepatitis B vaccination

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670 views • 42 slides
General considerations for clinical trials of vaccines

General considerations for clinical trials of vaccines

General considerations for clinical trials of vaccines. Ming-Hsiao Chan, MD,MPH Researcher/Team Leader, Division of Clinical Sciences, Center for Drug Evaluation, Taiwan. Disclaimer.

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779 views • 42 slides
Licensure of Pandemic Influenza Vaccines: Demonstration of Effectiveness

Licensure of Pandemic Influenza Vaccines: Demonstration of Effectiveness

Licensure of Pandemic Influenza Vaccines: Demonstration of Effectiveness. Vaccines and Related Biological Products Advisory Committee Meeting February 29, 2012. Theresa M. Finn, OVRR, CBER, FDA. Outline. Background Pandemic influenza Pandemic Planning 2007 Guidance for Industry

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699 views • 38 slides
Clinical Evaluation of Preventive Vaccines: Use of Bridging Studies

Clinical Evaluation of Preventive Vaccines: Use of Bridging Studies

Clinical Evaluation of Preventive Vaccines: Use of Bridging Studies. Marion F. Gruber, Ph.D. 2006 FDA/Industry Statistics Workshop Washington D.C., September 29, 2006. Objectives. Approval Process for Preventive Vaccines Applicable laws & regulations Clinical endpoint efficacy studies

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693 views • 36 slides
Outline

Outline

Vaccines and Related Biological Products Advisory Committee Meeting Hepatitis B Vaccine (Recombinant), Adjuvanted (HEPLISAV): Review of Immunogenicity Alexandra S. Worobec, M.D., M.S. FDA/CBER/OVRR/DVRPA November 15, 2012. Outline. Proposed Indication SPR as an ‘effectiveness’ endpoint

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570 views • 32 slides
Basic Principles of Immunohematology

Basic Principles of Immunohematology

Basic Principles of Immunohematology. Teaching Aims. To understand the basis of Immunology and genetics which are closely involved in the understanding of blood group serology. Antigen and Antibody. Antigen:

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6.64k views • 28 slides
Helen Fletcher, PhD Senior Lecturer in Immunology, London School of Hygiene and Tropical Medicine

Helen Fletcher, PhD Senior Lecturer in Immunology, London School of Hygiene and Tropical Medicine

The MVA85A Phase IIb study in South African infants- what can we learn from this TB vaccine efficacy trial?. Helen Fletcher, PhD Senior Lecturer in Immunology, London School of Hygiene and Tropical Medicine. Why is TB vaccine development so difficult?. Rappuloi and Aderem, Nature 2012.

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476 views • 26 slides
Antigens

Antigens

Antigens. Dr. Conrad Sept. 4, 2009. ANTIGENS Objectives: At the end of the lecture students will be able to:

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501 views • 23 slides
Statistical Comparison of Immunogenicity Cutpoint Factors Using Log Transformation

Statistical Comparison of Immunogenicity Cutpoint Factors Using Log Transformation

Statistical Comparison of Immunogenicity Cutpoint Factors Using Log Transformation. Dingzhou (Dean) Li PharmaTx Statistics, Pfizer Global R&D MBSW, 2010. Definitions. Immunogenicity: Causing or capable of producing an immune response. Unwanted for target-binding drugs

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1k views • 22 slides
Antigens

Antigens

Antigens. Jennifer Nyland, PhD Office: Bldg#1, Room B10 Phone: 733-1586 Email: jnyland@uscmed.sc.edu. Teaching objectives. To compare and contrast immunogen , antigen & hapten To describe the factors influencing immunogenicity To define the chemical nature of immunogens

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623 views • 19 slides
Antigens

Antigens

Antigens. Jennifer Nyland, PhD Office: Bldg#1, Room B10 Phone: 733-1586 Email: jnyland@uscmed.sc.edu. Teaching objectives. To compare and contrast immunogen , antigen & hapten To describe the factors influencing immunogenicity To define the chemical nature of immunogens

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260 views • 19 slides
Immunogenicity Overview of Therapeutic Biologics

Immunogenicity Overview of Therapeutic Biologics

What is immunogenicity? The concept of immunogenicity is more complex. In the video, Immunogenicity is defined as the propensity of the therapeutic biologics to generate immune responses to itself and to related proteins or to induce immunologically related non clinical affect or adverse clinical events. There are two types of immunogenicity in therapeutic biologics development process: wanted immunogenicity and unwanted immunogenicity Wanted immunogenicity is typically related with vaccines, where the injection of an antigen (the vaccine) stimulates an immune response against the pathogen (virus, bacteria, cancer cell...) aiming at protecting the organism. Unwanted immune responses to therapeutic biologics may also neutralize their biological activities and result in adverse events not only by inhibiting the efficacy of the therapeutic biologics, but also by cross-reacting to an endogenous protein counterpart, leading to loss of its physiological function (e.g., neutralizing antibodies to therapeutic erythropoietin cause pure red cell aplasia by also neutralizing the endogenous protein). The meaning of immunogenicity in this overview is the latter adverse immune response in the therapeutic biologics discovery and development.

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211 views • 11 slides
Immunogenicity overview of therapeutic biologics

Immunogenicity overview of therapeutic biologics

Immunogenicity overview of therapeutic biologics

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267 views • 11 slides
Diagnostic of infectious diseases

Diagnostic of infectious diseases

Diagnostic of infectious diseases. Direct diagnostic . Visualisation -microscopy -antigen detection -cultivation -genetic matierial detection Indirect diagnostic: - detection of the reaction of macroorganism to the presence of microorganism Specific reaction of immune system

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656 views • 9 slides
H Liu et al. Nature 000 , 1-4 (2014) doi:10.1038/nature12978

H Liu et al. Nature 000 , 1-4 (2014) doi:10.1038/nature12978

Amph-vaccines maximize the immunogenicity and therapeutic efficacy of polypeptide vaccines. H Liu et al. Nature 000 , 1-4 (2014) doi:10.1038/nature12978.

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125 views • 1 slides
SENDAI Protocol

SENDAI Protocol

SENDAI Protocol

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155 views • 1 slides

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