'Hif 1' presentation slideshows

Outline O 2 discovery O 2 sensing O 2 utilization Non-shivering Thermogenesis -Brown fat

Oxygen. The capable electron acceptor. Outline O 2 discovery O 2 sensing O 2 utilization Non-shivering Thermogenesis -Brown fat -Amino-acids. Photosystem I. e - tp chain. Light ( 4 photons ). Photosystem II. ATP. Chlorophyll. ADP. O 2 + 4H +. 4e -. e - tp chain.

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Pharminox SAB - 23 March 2009

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Pharminox SAB - 23 March 2009

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Autophagy 6:6, 725-737; August 16, 2010

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Possible fates of glucose

Possible fates of glucose. Glycolysis glykys = sweet, lysis =splitting; degradation of glucose the process of the largest carbon flux in most cells sole energy source for many kinds of cells (e.g. erythrocytes, brain, renal medulla, sperm )

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Metabolism and Cancer

Metabolism and Cancer. Bob Harris D-3034 Roudebush VA Medical Center 988-4544 raharris@iupui.edu. Fall 2010. Metabolism and Cancer. Objectives: Define and explain the Pasteur effect. Define and explain the Warburg effect. Define aerobic glycolysis.

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Outline

Elevated Beclin 1 expression is correlated with HIF-1α in predicting poor prognosis of nasopharyngeal carcinoma.

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TEMSIROLIMUS

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?? TPZ ???? Q39 ?????????

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Supplemental Figure 1.

Supplemental Figure 1. a. db/m db/db db/db + fasudil. b. db/m db/db db/db + fasudil. c. db/m db/db db/db + fasudil. NS. Supplemental Figure 2. Hypoxia. ? ? ? ?. Y-27632. ? ? ? ?. Supplemental Figure 3. a. b. c. DFX.

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Fig. S1. Effect of TG2 expression on LNCaP cell growth (A) and

Fig. S1. Effect of TG2 expression on LNCaP cell growth (A) and Karyotyping of parental, vector-infected and TG2-transfected LNCaP cells (B). B. A. Relative cell growth over 3 days. LNCaP LNCaP -EV LNCaP -TG2.

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Fig. S1. Effect of TG2 expression on LNCaP cell growth (A) and

Fig. S1. Effect of TG2 expression on LNCaP cell growth (A) and Karyotyping of parental, vector-infected and TG2-transfected LNCaP cells (B). B. A. Relative cell growth over 3 days. LNCaP LNCaP -EV LNCaP -TG2.

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30nM EGF: - + - + - + - + - +

Supplementary Fig. 1. SB203580: + +. UO126: + +. AG1478: + +. LY294002: + +.

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RELEVANT IMPACT

Does the Utility of Endogenous Markers of Hypoxia Differ by Tumour HPV Status in Head & Neck Cancer?. Nigel Brockton 1,2 , Joseph Dort 2,3,4 , Harold Lau 2 , Desiree Hao 2 , Sony Brar 1 , Corinne Doll 2 , Anthony Magliocco 2,5

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Pol b FEN1 APE1

+. +. +. +. +. +. +. Figure 4. Genome instabilit y. Genome instability. APE1/ ANPG. Progression. Progression. APC mutated. Pol b FEN1 APE1. AID - mediated d e methylation of gene promoters. Transcription of several genes. TDG/MBD4. TP53 mut ated.

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Off

Notch. Hedgehog. Hypoxia. HDAC. ARNT. Repressor. SMRT. E1A. CSL. E1A. E1A. Ci-75. Off. PCAF. CBP. CBP. ARNT. HIF-1 ?. NotchIC. CSL. E1A. E1A. E1A. Ci. On. NotchIC. ARNT. HIF-1 ?. CSL. Ci. X-E1A. X-E1A. X-E1A. Positive Feedback. E1A. E1A. E1A. X. X. X.

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DU145

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5-FU + folinic acid (n= 133)

281 patients with St. IIb/III CRC. Dropout due to missing data or missing Tumor blocks (n = 12). R. 5-FU + folinic acid + irinotecan (n = 136). 5-FU + folinic acid (n= 133). AREG+ (n= 10). AREG- (n= 84). EREG+ (n= 21). EREG- (n= 69). AREG+ (n= 11). AREG- (n= 80). EREG+

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PU-H71

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ctrl

Supplementary Figure S4. SiHa /7.4. SiHa /6.5. EX-527. A. B. EX-527. ctrl. ctrl. IP:. Ac-Lys. HIF-1 ?. HIF-1 ?. Ac-Lys. HIF-2 ?. HIF-2 ?. SIRT1. inputs. actin. C. D. E. SiHa/7.4. SiHa/6.5. Flag-SIRT1 wild -type. -. +. -. -. +. -. Flag-SIRT1 H363Y. -. -. +. -.

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