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Herman sem et al - PowerPoint PPT Presentation

Ibrutinib : First-in Class Inhibitor of BTK

O. N. H. 2. N. N. N. N. N. O. Ibrutinib : First-in Class Inhibitor of BTK. Forms a specific and irreversible bond with cysteine-481 in BTK Highly potent BTK inhibition at IC 50 = 0.5 nM Orally administered with once daily dosing resulting in 24-hr target inhibition

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Ibrutinib : First-in Class Inhibitor of BTK