'Friedel crafts' presentation slideshows

Patrick An Introduction to Medicinal Chemistry 3/e Chapter 12 DRUG DESIGN & DEVELOPMENT

Patrick An Introduction to Medicinal Chemistry 3/e Chapter 12 DRUG DESIGN & DEVELOPMENT. Contents 1. Preclinical trials 1.1. Chemical Development (2 Slides) 1.2. The Initial Synthesis (3 Slides) 1.3. Optimisation of Reactions 1.3.1. Temperature 1.3.2. Pressure (2 Slides)

1.58k views • 68 slides

Chap 15 Electrophilic aromatic substitution ( ????????

Chap 15 Electrophilic aromatic substitution ( ????????. 15.1 Electrophilic aromatic substitution reactions These reactions are of the general type shown below;. E + -------Electrophilic reagent ????. Fig 15.1 Electrophilic aromatic substitution reactions.

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Arenes : compounds containing both aliphatic and aromatic parts. Alkylbenzenes Alkenylbenzenes

Arenes : compounds containing both aliphatic and aromatic parts. Alkylbenzenes Alkenylbenzenes Alkynylbenzenes Etc. Emphasis on the effect that one part has on the chemistry of the other half. Reactivity & orientation. Example: ethylbenzene EAS in the aromatic part

529 views • 52 slides

Chapter 22

Chapter 22. Reaction of Benzene and its Derivatives. Reactions of Benzene. Substitution at a ring carbon. Contrast to radical mechanism for benzylic hyrdogens. Reactions of Benzene. Friedel Crafts. Friedel Crafts. Electrophilic Aromatic Substitution.

686 views • 51 slides

Bromination of Benzene

Bromination of Benzene. Mechanism for the Bromination of Benzene: Preliminary Step. Before the electrophilic aromatic substitution can take place, the electrophile must be activated. A strong Lewis acid catalyst, such as FeBr 3 , should be used.

1.03k views • 49 slides

Chapter 17 Reactions of Aromatic Compounds

Organic Chemistry , 6 th Edition L. G. Wade, Jr. Chapter 17 Reactions of Aromatic Compounds. Electrophilic Aromatic Substitution. Electrophile substitutes for a hydrogen on the benzene ring. Step 1: Attack on the electrophile forms the sigma complex.

494 views • 29 slides

Chapter 17 Reactions of Aromatic Compounds

Organic Chemistry , 6 th Edition L. G. Wade, Jr. Chapter 17 Reactions of Aromatic Compounds. Electrophilic Aromatic Substitution. Electrophile substitutes for a hydrogen on the benzene ring. Step 1: Attack on the electrophile forms the sigma complex.

454 views • 29 slides

Ionic Liquid

Green Chemistry Presentation. Ionic Liquid. Presented by :Xin Huang. Development. Outline. Definition. Advantage. Applications. Ionic liquid in synthesis. Examples. Conclusion. What are Ionic Liquids. Common Definition.

3.81k views • 29 slides

Bismuth in Organic Synthesis

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Calculations for Exp.1: Solvolysis of tert Butyl Chloride

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Examples of Carbocation Formation

=>. Examples of Carbocation Formation. -. +. =>. Formation of Alkyl Benzene. Limitations of Friedel-Crafts. Reaction fails if benzene has a substituent that is more deactivating than halogen.

393 views • 10 slides