Ezetimibe - PowerPoint PPT Presentation

New Approaches to LDL Reduction

New Approaches to LDL Reduction. Cholesterol Absorption Inhibitors. Liver synthesis. Inhibition of Cholesterol Absorption and Production With Ezetimibe / Simvastatin. Simvastatin. Ezetimibe. 1000 mg/day. Dietary cholesterol. ~300 mg/day–700 mg/day. Biliary cholesterol. ~1000 mg/day.

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256 views • 23 slides

Background and Objective

Background and Objective. In the recently reported Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) trial, the combination of ezetimibe/simvastatin (E/S) was associated with a significantly increased risk of cancer compared to placebo, causing widespread public concern.

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237 views • 9 slides

Tremblay AJ. Et al. J Lipid Res 2009 Mar 22 [Epub ahead of print]

Tremblay AJ. Et al. J Lipid Res 2009 Mar 22 [Epub ahead of print]. Lipid/Lipoprotein Profile After a 6-Week Treatment with Ezetimibe (10 mg/d) and Simvastatin (40 mg/d), Simvastatin (40 mg/d) alone, Ezetimibe (10 mg/d) alone and Placebo.

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210 views • 6 slides

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