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Chemical constituents of Solanum xanthocarpum

Chemical constituents of Solanum xanthocarpum

Solanum xanthocarpum is a spiny diffuse herb and used in medicine in various forms, such as decoction, electuary, ghrita, etc. Its roots are one of the constituents of well known Ayurvedic preparation “Dasmula Ashva”. Phytochemical investigation of the ethyl acetate extract of the roots of Solanum xanthocarpum growing in Ramnagar region led to the isolation of caffeic acid and oleanolic acid using different chromatographic methods (i.e. paper, thin layer, and column chromatography). The structure of these compounds was determined by extensive IR, UV, and NMR spectroscopy.

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Inhibitory activity of Euphorbia hirta (Tawa- tawa) extracts against Mycobacterium tuberculosis and other non mycobacter

Inhibitory activity of Euphorbia hirta (Tawa- tawa) extracts against Mycobacterium tuberculosis and other non mycobacter

Methanol, ethyl acetate and n-hexane extracts from the leaves of Euphorbia hirta were screened against nonmycobacterial pathogens and Mycobacterium tuberculosis H37Rv using agar well diffusion and Luciferase Reporter Phage (LRP) assay, respectively. Methanol extract of Euphorbia hirta showed 10-15 mm inhibition against B. subtilis, E. coli, and V. cholerae at 100µg/ml whereas no activity was observed against S. aureus and E. faecalis. The ethyl acetate extract showed activity only B. subtilis (12mm) and E. faecalis (10mm) while n- hexane extract showed no activity. In LRP assay, the ethyl acetate extract showed better activity with maximum of 64.73% reduction in RLU against M. tuberculosis H37Rv compared to methanol and n-hexane extracts. Further bioassay guided fractionation is in progress for the isolation, characterization and identification of active principle from Euphorbia hirta leaves.

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