'Essential genes' presentation slideshows

Deeply investigating and analysis chemical genome wide fitness data. Predict gene-functional

Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action. M. Hillenmeyer (Stanford), E. Ericson (Toronto), R. Davis (Stanford), C. Nislow (Toronto), D. Koller (Stanford) and G. Giaever (Toronto) Published in Genome Biology 2010

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Synthetic Lethality

Synthetic Lethality. X. A. X. Viable!. Y. B. X. Viable!. Z. C. Product. Dead!. Inactivating two interacting pathways causes lethality (or sickness). A. A. a D. a D. X. X. B. B. b D. b D. Wild-type. Viable. Viable. Lethal. Synthetic Lethality.

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Synthetic Biology

827 views • 34 slides

Chapter 3: How many genes are there?

Chapter 3: How many genes are there?. 3.1 Introduction Total number of genes at four levels: genome is the complete set of genes of an organism transcriptome is the complete set of genes expressed under particular conditions proteome is the complete set of proteins

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- J. Maniloff PNAS 93, pp. 10006

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- J. Maniloff PNAS 93, pp. 10006

400 views • 32 slides

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Identifying essential genes in M. tuberculosis by random transposon mutagenesis

Identifying essential genes in M. tuberculosis by random transposon mutagenesis. Karl W. Broman Department of Biostatistics Johns Hopkins University http://www.biostat.jhsph.edu/~kbroman. Mycobacterium tuberculosis. The organism that causes tuberculosis Cost for treatment: ~ $15,000

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DESIGNING A SYNTHETIC ORGANISM

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Tim17:23 Membrane location (Yeast)

How do we test function of yeast homologues in animals and plants as lethal if mutated or deleated - in both yeast and higher eukaryotes. Tim17:23 Membrane location (Yeast). Tim17:23 Import channel on inner membrane Recently shown that channel activity associated with Tim23.

374 views • 26 slides

Choukri B.M., I.Y. Gluzman, S. Goyard, S.M. Beverley, and D.E. Goldberg

A set of independent selectable markers for transfection of the human malaria parasite Plasmodium falciparum . Choukri B.M., I.Y. Gluzman, S. Goyard, S.M. Beverley, and D.E. Goldberg Presented by Roody Pierre-Charles. The Mosquito, the primary carrier of Malaria.

427 views • 24 slides

Functional profiling of the S. cerevisiae genome

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Functional profiling of the S. cerevisiae genome

Functional profiling of the S. cerevisiae genome. G Giaever, et al. What is the question? What are they looking at? Why is this genomics instead of genetics?. Why is this better than classical genetics?. Mutant phenotype reflects a deletion, i.e. complete loss of function

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Origins and impact of constraints in evolution of gene families

Origins and impact of constraints in evolution of gene families Boris E. Shakhnovich and Eugene V.Koonin Genome Research 2006, October 19. Stella Veretnik. Journal Club November 14, 2006. Essential genes and their families: diverge more slowly than non-essential genes

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Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis

Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Winzeler, et al. Review - libraries. Genomic cDNA Other What are the advantages and disadvantages of each?

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Amino Acid Biosynthesis

Amino Acid Biosynthesis. By Laura Voss. Biosynthesis vs. Metabolism. Not the same as amino acid metabolism pathways. Synthesis of most amino acids is only one or two steps removed from another pathway or cycle.

364 views • 13 slides

MUTATIONS

MUTATIONS. CHROMSOMES AND GENES. THE IMPACT OF MUTATION. There are 2 types of mutations 1. Chromosomal: changes in the fundamental structure of a chromosome which most likely occur during crossing over at meiosis. 2. Gene: Changes in the nucleotide sequence Both types of mutations:

287 views • 13 slides

Genetic Engineering

Genetic Engineering. What is Genetic Engineering?. Genetic Engineering = inserting a foreign gene of interest into a host to transcribe and translate a particular protein. Ex. Inserting the human insulin gene into bacteria to mass produce it.

219 views • 11 slides