'Electron withdrawing resonance effect' presentation slideshows

What happens when there is a substituent already present? Where does the second substitution go?

What happens when there is a substituent already present? Where does the second substitution go? Is the attack by the second electrophile directed, or is its approach strictly random?. In order to answer this kind of question, let us examine two typical examples:. The Nitration of Anisole.

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