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Monitoring and inhibiting phase separation of amorphous solid dispersions

Pharmaceutica 2015 Dubai 16 th April 2015. Monitoring and inhibiting phase separation of amorphous solid dispersions. Dr Min Zhao Min.zhao@ucl.ac.uk Department of Pharmaceutics UCL School of Pharmacy, UK. 1. Content.

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LACTIC ACID AS SPACER BETWEEN POLY ACRYLIC ACID AND 4- AMINOANTIPYRINE

Due to many problems associated with drug release and side effects, we could design a novel drug delivery system through modification of poly acrylic acid (AA) with Lactic acid as a spacer between the polymer and 4-aminoantipyrine. In vitro drug release had been conducted successfully in basic medium in pH 7.4 and acidic medium in pH 1.1 at 37?. The prepared prodrug polymer was characterized by FTIR and 1H?NMR spectra. Physical properties and intrinsic viscosity of drug polymer were determined. The good results were obtained in the presence of spacer unit with comparing without spacer unit.

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Drug polymer - PowerPoint PPT Presentation

Monitoring and inhibiting phase separation of amorphous solid dispersions

LACTIC ACID AS SPACER BETWEEN POLY ACRYLIC ACID AND 4- AMINOANTIPYRINE