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PK/PD: TOWARDS DEFINITIVE CRITERIA

PK/PD: TOWARDS DEFINITIVE CRITERIA

PK/PD: TOWARDS DEFINITIVE CRITERIA. PK/PD in clinical Practice: new level of PK/PD. Francesco Scaglione Department of Pharmacology, Toxicology and Chemotherapy, University of Milan, Milan, Italy. PK/PD results and evolution. }. }. Improvement of dose and intervals. Outcome resistance.

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568 views • 36 slides
Patterns of Antimicrobial Activity

Patterns of Antimicrobial Activity

Pharmacodynamics of Antimicrobials in Animal Models William A. Craig, M.D. University of Wisconsin-Madison. Patterns of Antimicrobial Activity. Concentration-dependent killing and prolonged persistent effects Seen with aminoglycosides, quinolones, daptomycin, ketolides and amphotericin B

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462 views • 31 slides
Dosing Regimen Design

Dosing Regimen Design

Dosing Regimen Design. Multiple Dosing: Intermittent or multiple dose regimen. 100 mg q. t 1/2 via i.v. bolus. 200. 150. Amount in Body [mg]. 100. 50. Time [t 1/2 ]: 1 2 3 4 5 6. Principle: 1 dose lost per ?.

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929 views • 29 slides
Effect of Increasing Concentrations on Killing of Pneumococci in Thighs of Neutropenic Mice

Effect of Increasing Concentrations on Killing of Pneumococci in Thighs of Neutropenic Mice

Pharmacodynamics of Antimicrobials in Animal Models William A. Craig, M.D. University of Wisconsin-Madison. Effect of Increasing Concentrations on Killing of Pneumococci in Thighs of Neutropenic Mice. Telithromycin. Azithromycin. Clarithromycin. 8. 6. Log 10 CFU per Thigh. 4. 4. 0. m.

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386 views • 29 slides
SYSTEMIC ANTIFUNGAL AGENTS SPECTRUM INDICATIONS PRECAUTIONS

SYSTEMIC ANTIFUNGAL AGENTS SPECTRUM INDICATIONS PRECAUTIONS

SYSTEMIC ANTIFUNGAL AGENTS SPECTRUM INDICATIONS PRECAUTIONS. DR ALPAY AZAP Ankara University Medical School Infectious Diseases and Clinical Microbiology Dept. Anidulafungin. Caspofungin. Ravucon. XMP. Sordarins. Micafun. Voricon. Posacon. # of Antifungals. L-AmB ABCD

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567 views • 24 slides
Ameeta Parekh, Ph.D. CDER/OCPB CPSC Meeting November 17/18

Ameeta Parekh, Ph.D. CDER/OCPB CPSC Meeting November 17/18

Benefits and Applications of Exposure Response Relationship in Drug Development and Approval Case Studies. Ameeta Parekh, Ph.D. CDER/OCPB CPSC Meeting November 17/18. Presentation Outline. FDA/Industry Interactions: Milestones During Drug Development

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531 views • 20 slides

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