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Biometrical genetics

Biometrical genetics

Biometrical genetics. Manuel AR Ferreira. Massachusetts General Hospital. Harvard Medical School. Boston. Boulder, 2008. Revisit common genetic parameters - such as allele frequencies, genetic effects, dominance, variance components, etc.

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1.14k views • 58 slides
Genetic principles for linkage and association analyses

Genetic principles for linkage and association analyses

Genetic principles for linkage and association analyses. Manuel Ferreira & Pak Sham. Boulder, 2009. Gene mapping. LOCALIZE and then IDENTIFY a locus that regulates a trait. Association analysis. Linkage analysis. Linkage:.

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755 views • 58 slides
Biometrical genetics

Biometrical genetics

Biometrical genetics. Manuel Ferreira Shaun Purcell Pak Sham. Boulder Introductory Course 2006. Outline. 1. Aim of this talk. 2. Genetic concepts. 3. Very basic statistical concepts. 4. Biometrical model. 1. Aim of this talk.

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681 views • 55 slides
Biometrical genetics

Biometrical genetics

Biometrical genetics. Pak C Sham The University of Hong Kong Manuel AR Ferreira Queensland Institute for Medical Research. 23 rd International Workshop on Methodology of Twin and Family Studies 2 nd March, 2010. A DE Model for twin data. 1 / 0.25. MZ / DZ. 1 / 0.5. E 1. D 1. A 1.

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558 views • 53 slides
NORMAL DISTRIBUTIONS OF PHENOTYPES

NORMAL DISTRIBUTIONS OF PHENOTYPES

NORMAL DISTRIBUTIONS OF PHENOTYPES. Mice. Fruit Flies. In: Introduction to Quantitative Genetics Falconer & Mackay 1996. MEAN. VARIANCE. CHARACTERIZING A NORMAL DISTRIBUTION. Mean and variance are two quantities that describe a normal distribution.

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292 views • 29 slides
Lecture 2: Basic Population and Quantitative Genetics

Lecture 2: Basic Population and Quantitative Genetics

Lecture 2: Basic Population and Quantitative Genetics. Allele and Genotype Frequencies. Given genotype frequencies, we can always compute allele frequencies, e.g.,. The converse is not true: given allele frequencies we cannot uniquely determine the genotype frequencies.

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619 views • 23 slides
PBG 650 Advanced Plant Breeding

PBG 650 Advanced Plant Breeding

PBG 650 Advanced Plant Breeding. Module 5: Quantitative Genetics Genetic variance: additive and dominance. Variance and Covariance - definition. The variance of a variable X is: V( X ) = E[( X i - ? X ) 2 ] = E( X i 2 ) - ? X 2 The covariance of variable X and variable Y is:

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556 views • 19 slides

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