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Adventures in Computational Enzymology

Adventures in Computational Enzymology

Adventures in Computational Enzymology. John Mitchell. MACiE Database. M echanism, A nnotation and C lassification i n E nzymes . http://www.ebi.ac.uk/thornton-srv/databases/MACiE/. G.L. Holliday et al ., Nucl. Acids Res ., 35 , D515-D520 (2007). EC Classification. Class. Subclass.

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1.05k views • 87 slides
Methods for comparing protein structures Protein structural classifications

Methods for comparing protein structures Protein structural classifications

Comparing and Classifying Domain Structures. Methods for comparing protein structures Protein structural classifications How do structures and functions diverge in protein superfamilies What proportion of genome sequences can be predicted to belong to superfamilies of known structure?.

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498 views • 49 slides
The evolution of domain superfamilies from a structural and functional perspective

The evolution of domain superfamilies from a structural and functional perspective

The evolution of domain superfamilies from a structural and functional perspective. Oliver Redfern CATH-GENE3D group Dept. Structural and Molecular Biology University College London UK. The CATH and Gene3D Domain and protein family resources (sequence, structure, function).

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581 views • 41 slides
Modules

Modules

Another example of the helix-loop-helix motif is seen within several DNA binding domains including the homeobox proteins which are the master regulators of development. Modules. HMMs, Profiles, Motifs, and Multiple Alignments used to define modules. (Figures from Branden & Tooze).

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489 views • 34 slides
Imaging x-ray generation and Scattering

Imaging x-ray generation and Scattering

Imaging x-ray generation and Scattering. Tabletop soft x-ray coherent imaging microscopes. High Harmonic Generation for ultrafast soft x-rays. Ti:sapphire seed laser. Diode pump. Pump beam. Amplifier pump. Regenerative amplifier 3mJ, 35fs, 1kHz. Vacuum chamber. Gas cell. CCD camera.

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346 views • 21 slides
A Policy-Based Framework for e-Health Application

A Policy-Based Framework for e-Health Application

A Policy-Based Framework for e-Health Application. Jatinder Singh Jean Bacon Ken Moody University of Cambridge. Giovanni Russello Changyu Dong Naranker Dulay Imperial College London. Caregrid Project. Main project goal :

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297 views • 20 slides
Ferroelasticity

Ferroelasticity

Ferroelasticity. Bratkovsky et al., 1996. Background. Set. As T approaches the transition temperature, the shear modulus goes to zero and the material loses strength. Characteristic hysteresis of ferroelastic materials. Salje, 2000. Spontaneous strain due to phase transitions.

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273 views • 17 slides
T Bretschneider et al. Nature 000 , 1 - 5 (2013) doi:10.1038/nature 12588

T Bretschneider et al. Nature 000 , 1 - 5 (2013) doi:10.1038/nature 12588

Domain structures of branching module (RhiE*). T Bretschneider et al. Nature 000 , 1 - 5 (2013) doi:10.1038/nature 12588.

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109 views • 1 slides

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