'Disintegration time keeping weight' presentation slideshows

Selection of superdisintegrant for Famotidine rapidly disintegrating tablets

Patient groups such as elderly, children, and patients mentally retarded, uncooperative, nauseated, or on reduced liquid intake diets have difficulty in swallowing tablet dosage forms. For a rapidly disintegrating tablet, selection of superdisintegrant is of prime importance. This paper aimed in determining the optimum concentration of superdisintegrants and effect of hardness on disintegration time. 2, 4, 6% w/w concentration of superdisintegrants (sodium starch glycollate, crospovidone, croscarmellose sodium and Methacrylic copolymer with divinyl benzene) were used for this purpose. Famotidine which belongs to a class of medications called H2-antagonists was selected as a suitable candidate. 4% Crospovidone was most effective as a superdisintegrant for Famotidine. It was seen that as hardness increased, the D.T. increased with all concentration of superdisintegrant. Superdisintegrants when used in combination did not show that much remarkable decrease in disintegration time as compared to the individual. Stability studies of the formulation suggest that there was no degradation with respect to time. IR data indicated no interaction of drug with the excipients.

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