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Pre-genomic era: finding your own clones

Pre-genomic era: finding your own clones. Imagine initial cDNA or PCR fragment probe hybridizes to clones 3, 9, 16, 22. GENOME. 1. 2. 3. 23. CHROMOSOMES. YACs. or. BACs (map). Plasmid Sub-clones. Gridded (arrayed/ordered) library. 18,000 BACs for Drosophila. 300,000 BACs for Humans.

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Beaming beads - PowerPoint PPT Presentation

Pre-genomic era: finding your own clones