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Apaf 1 - PowerPoint PPT Presentation

Imad Fadl-Elmula

Imad Fadl-Elmula

APOPTOSIS PROGRAMMED CELL DEATH. Imad Fadl-Elmula. History. Described first by Kerr et al., (1972). Apoptosis derived from Greek "falling off" (as for autumn leaves). Importance. Essential for physiological and developmental process Embryonic development.

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585 views • 42 slides
Cancer results from mutations in genes regulating cell growth

Cancer results from mutations in genes regulating cell growth

Cancer results from mutations in genes regulating cell growth. Two classes of genes are involved: 1) - positive regulators promote cancer by hyperactivity (one allele is enough)

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524 views • 41 slides
DRACO

DRACO

www.RiderInstitute.org

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422 views • 28 slides
Involvement of Histone H1.2 in Apoptosis Induced by DNA Double-Strand Breaks

Involvement of Histone H1.2 in Apoptosis Induced by DNA Double-Strand Breaks

Involvement of Histone H1.2 in Apoptosis Induced by DNA Double-Strand Breaks. Konishi et al., Cell, Vol 114, 673-688, 2003. RCC1 ( inxs/Bj1 ). Regulator of Chromatin Condensation-1:

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329 views • 24 slides
Bcl-2

Bcl-2

Bcl-2. Sarah A. Norris. Apoptosis. Programmed cell death. http://virtuallaboratory.net/Biofundamentals/lectureNotes/Topic5-4_CellDeath.htm. http://upload.wikimedia.org/wikipedia/commons/8/8a/Bcl-2_Family.jpg. Bcl-2 Structure. Encodes an integral membrane protein.

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424 views • 19 slides
Apoptosis

Apoptosis

Apoptosis. Many functions for programmed cell death, many consequences for failure of its regulation Apoptosis vs. necrosis Intrinsic and extrinsic pathways for survival vs. proliferation vs. apoptosis Caspases: activation by proteolysis Mitochondria and cytochrome c release BCL-2 proteins.

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229 views • 17 slides
Cell Cycle Regulation

Cell Cycle Regulation

Cell Cycle Regulation.

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125 views • 7 slides
Procasp.-9 mut + + + + - +

Procasp.-9 mut + + + + - +

A. B. IP:C-9. IP:FLAG. TOTAL. IP:C-9. TOTAL. Procasp.-9 mut + + + + - + TUCAN-FLAG + + + + + - cyt.c/dATP + - + - - -. Procasp.-9 mut + + -

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150 views • 1 slides
Caspase Activation Intrinsic Pathway

Caspase Activation Intrinsic Pathway

Caspase Activation Intrinsic Pathway. SIGMA-ALDRICH.

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199 views • 1 slides
ERK2

ERK2

apaf-1 -/-. p53. p21. ERK2. TPT (h). C 1 2 4 8. Supplemental Figure 1.

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165 views • 1 slides

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