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Insights on Aging: The Danish Aging Research Center's Plan for the Future

Explore the groundbreaking research on aging at the Danish Aging Research Center (DARC). Discover why individuals age differently and delve into the impact of cholesterol on longevity and mortality. With clinical findings and observational studies, uncover the secrets of aging through twin comparisons and cohort data analysis. Gain insights into exceptional longevity and disability levels in the 1905 cohort. Join the quest for understanding the complexities of aging and the pursuit of healthier aging outcomes.

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Insights on Aging: The Danish Aging Research Center's Plan for the Future

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  1. Plan for the coming years VELUX FONDEN Why do we age so differently? - D A N I S H A G I N G R E S E A R C H C E N T E R - www.sdu.dk/darc

  2. Danish Aging Research Center

  3. Greenhouse Project Line Kirkeby Petersen, MD: Cholesterol and Aging Observational studies: Low cholesterol good among younger elderly but associated with higher mortality among the Oldest-Old Clinical practice: Cholesterol lowering drugs áá

  4. Cholesterol and Mortality • 274 twin pairs age 73-94 • Blood samples 1997 • Follow-up to 2009 • Deaths:289 twins 244 pairs with at least one dead twin • Intrapair comparison: Control for age, sex, genetic factors

  5. 1905 Cohort - Denmark 314 Drop-outs 127 Drop-outs 58 Drop-outs 2,262 (63%) 1,086 (78%) 437 (77%) 166 (74%) 862 died 522 died 213 died 1998 2000 2003 2005

  6. 92 years – half way to 100 1:30 1:30 ♂ 0 92 100 1:10 1:10 0 92 100 ♀ 1:15 1:15 0 92 100 ♂ +♀

  7. PARAOXONASE 1 (PON) 1.00 0.75 0.50 0.25 0.00 0 1000 2000 3000 analysis time genotype = QQ genotype = QR genotype = RR Cross-sectional twin data show association Independent replication in 1905 cohort

  8. The Fourth Age Does exceptional longevity lead to exceptional levels of disability?

  9. Independence in the 1905-Cohort Christensen et al. PNAS, 2008

  10. Independence in the 1905-Cohort Christensen et al. PNAS, 2008

  11. The Failure of Success? 1895 1905 1915

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