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Understanding B Cell Maturation and Humoral Immune Response

Explore the intricate process of B cell maturation, antigen recognition, and the orchestration of the humoral immune response. Discover the role of Btk gene mutation, key antigen receptors, and functional consequences of B cell activation. Gain insights into primary and secondary antibody responses in this comprehensive overview.

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Understanding B Cell Maturation and Humoral Immune Response

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  1. B cells Humoral immune response

  2. Antigen receptors on lymphocytes B cell T cell Antigens: proteins, polysaccharides, lipids, nucleic acids, small molecules Conformational and linear epitops Complex of peptide-MHC moleculeon an APC Linear epitops

  3. B cell maturation

  4. B cell maturation

  5. pro B

  6. pre B receptor pre B pro B

  7. Active Btk enables: survival, proliferation and further maturation etc. Mutation of BTK gene: X-linked agammaglobulinemia (Bruton’s agammaglobulinemia) Btk (Bruton’s tyrosine kinase)

  8. IgM pre B receptor immature B pre B pro B

  9. IgM pre B receptor pre B IgD IgM mature B immature B pro B

  10. IgD IgM MHC II CD40 B-7

  11. Humoral immune response Thymus-independent (T-independent, TI) Thymus-dependent (T-dependent, TD)

  12. Subsets of B cells

  13. Phases of humoral immuneresponse

  14. Activation of B cells (two-signal requirement)

  15. Activation of B cells (intracellular signaling)

  16. Functional consequencesof B cell activation

  17. Functional consequencesof B cell activation

  18. Functions of antibody isotypes

  19. Primary and secondary antibody response

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