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Effects of Immunosuppression on Hepatic PBGD Activity Over a 25-Week Period

This study examines the impact of immunosuppression on Hepatic PBGD activity over 25 weeks, comparing normal ranges, mRNA expression, and outcomes in non-injected NHP001, and injected NHP002 and NHP003 animals. The analysis covers changes in PBGD activity and mRNA expression levels in the liver.

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Effects of Immunosuppression on Hepatic PBGD Activity Over a 25-Week Period

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  1. A) Immunosuppression period *** 18 16 * 14 Hepatic PBGD activity (pmol URO/mg prot/h) 12 Normal range 10 8 6 weeks 0 5 10 15 20 25 NHP001 w/o IS NHP002 with IS NHP003 with IS ** 25 20 PBGD expression mRNA (arbitrary units) 15 ** 10 * 5 0 0 non injected (n=4) NHP 001 NHP 002 NHP 003 x200 x200 x200 x200 x200 x200 B) C) NHP001 [2.2 ± 0.37%] NHP002 [5.5 ± 1.24%] NHP003 [2.2 ± 0.47%]

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