Osteoporosis. Excessive skeletal fragility leading to low trauma fractures. Intrinsic skeletal factors: low bone mass, unfavorable geometry at cortical bone sites, small bone size, poor bone structure at cancellous bone sites and sluggish or ineffective repair of microdamage.
WHO Criteria:bone mass values that is >2.5 SD below the young adult mean value.
BMD (bone mineral density):measured by techniques such as DXA (dual energy x-ray absorptiometry).
Taq I RFLP