Cold is Hot. Hypothermia has shown to be partially neuroprotective in term HIE.Three big trials have been conducted, CoolCap, NICHD, TOBY.Total of 767 newborn infants randomized.ICE trial 221 infants and neo.nEuro trial 129 infants.. Three Trials\' Results. TOBY trial and CoolCap trial did not show any reduction in death and disability, the primary outcome. Only the NICHD trial showed reduction. Meta-analysis showed reduction of 0.81 (0.71-0.93).ICE trial confirms the smaller studies of h9460
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