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Therapeutic Principles. . . Therapeutic Endpoints. Efficacy without toxicityHuman medicine: palliative therapy onlyVeterinary medicine: palliative therapy probably?Efficacy AND toxicityHuman and veterinary medicine: aggressive, curative therapyToxicity without efficacyTentative administrationYou may affect bone marrow ONLY rather than bone marrow AND tumorDrug ResistanceReduces tumor response, bone marrow still sensitiveNeither toxicity nor efficacy.

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