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Network Dynamics and Cell Physiology

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Network Dynamics and Cell Physiology

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    1. Network Dynamics and Cell Physiology John J. Tyson Department of Biological Sciences & Virginia Bioinformatics Institute

    2. The NGF signaling pathway of the previous slide is only one of many components of a signal transduction network in mammalian cells, which integrates and processes information from growth factors, anti-growth factors, death factors, cell-cell and cell-matrix adhesions, etc., resulting in changes in gene expression, cell proliferation or cell cycle arrest, or cell death (apoptosis). How are we to understand the signal processing carried out by a network of this complexity? Is the wiring diagram sufficient to account for the physiological attributes of mammalian cells in vitro or in vivo? If not, what is missing? From Hanahan & Weinberg (2000) Cell 100:57-70.The NGF signaling pathway of the previous slide is only one of many components of a signal transduction network in mammalian cells, which integrates and processes information from growth factors, anti-growth factors, death factors, cell-cell and cell-matrix adhesions, etc., resulting in changes in gene expression, cell proliferation or cell cycle arrest, or cell death (apoptosis). How are we to understand the signal processing carried out by a network of this complexity? Is the wiring diagram sufficient to account for the physiological attributes of mammalian cells in vitro or in vivo? If not, what is missing? From Hanahan & Weinberg (2000) Cell 100:57-70.

    12. Dynamical Perspective on Molecular Cell Biology Vector Field, Steady State, Bifurcation

    25. Review

    26. The Cell Cycle of Fission Yeast

    38. S phase and M phase start at the same timeS phase and M phase start at the same time

    43. The Cell Cycle of Budding Yeast

    52. The Dynamical Perspective

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