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Lupine- “Crooked Calf Disease”. Can it be related to birth defects in other species?. Case Problem Overview. Lupine caused significant calf losses in the Western United States (4,000+ calves from 12,000 cows died in one county) New human baby born in mountainous backcountry of NW California

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lupine crooked calf disease

Lupine- “Crooked Calf Disease”

Can it be related to birth defects in other species?

case problem overview
Case Problem Overview
  • Lupine caused significant calf losses in the Western United States (4,000+ calves from 12,000 cows died in one county)
  • New human baby born in mountainous backcountry of NW California
    • severe bone deformities in arms and hands
    • partial absence of forearm bones
    • absence of thumbs
    • medical history indicates deformities were not the result of genetics
  • Goats on the farm gave birth to deformed kids
  • Pregnant bitch was fed goat’s milk and had a litter of deformed puppies
  • Pregnant woman also drank goat’s milk during pregnancy
what is crooked calf disease
What is Crooked Calf Disease?
  • characterized by bone abnormalities in the forelimbs, spine, and skull
  • can be directly attributed to a pregnant mother’s ingestion of a specific lupine alkaloid, anagyrine
  • the alkaloids act as a sedative, keeping the fetus in an abnormal position, so that it continues to grow while fixed in that position. this causes the bone abnormalities.3
hypothesis
Hypothesis
  • We hypothesize that there is a relation between the birth defects of the human baby, goats, and dogs to the lupine induced “crooked calf disease”.
    • symptoms are similar
  • Goats grazing may have ingested the lupine alkaloid, which allowed the toxin in their system
    • it seems to be transmittable through milk
    • evidenced by the fact that both the woman and bitch drank the goat’s milk and had deformed offspring
evidence to support hypothesis
Evidence to support Hypothesis
  • Lupine ingestion is widely accepted as the cause of “crooked calf disease”
  • No direct evidence available between lupine and goats
  • Tests could be run to detect the presence of anagyrine in goat’s milk
    • it has been found that when goats are fed lupine seeds, anagyrine can be detected in the milk almost immediately.2
    • Investigations in test animals to determine how much of the anagyrine needs to be transferred to cause abnormalities
conclusions
Conclusions
  • Circumstances are too coincidental to be three separate, isolated incidents
  • appears to support hypothesis
references
References
  • 1.http://www.wisc.edu/ansci_repro/lab/lab12_03/lab12_cases/case7_goat.htm
  • 2. Kilgore, Wendell W., Crosby, Donald G.,  Craigmill, Arthur L., and Poppen, Norman K.
  • 3.
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