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Is there a link between inflammatory bowel disease and the metabolic syndrome? PowerPoint Presentation
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Is there a link between inflammatory bowel disease and the metabolic syndrome?

Is there a link between inflammatory bowel disease and the metabolic syndrome?

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Is there a link between inflammatory bowel disease and the metabolic syndrome?

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Presentation Transcript

  1. Is there a link between inflammatory bowel disease and the metabolic syndrome? Hester Franks Academic F2 Supervisors Professors Hawkey and Macdonald

  2. Background and hypothesis • Methods • Results to date

  3. Background and hypothesis • Inflammatory bowel disease (IBD) • Crohn’s disease (CD) • Ulcerative colitis (UC) • Metabolic syndrome • Genetic predisposition to both conditions • There seem to be an increasing number of obese patients in IBD clinics. • Is it possible that in the obese patients it is their obesity/the metabolic syndrome rather than these polymorphisms which predisposes them to IBD?

  4. Methods • 3 groups • CD BMI>28 • CD BMI<23 • Controls BMI>28 • 2 parts to study • Genetic analysis for SNPs & baseline metabolic analysis • Detailed analysis of fasting and postprandial metabolic state

  5. Results • So far • 167 UC patients • 110 CD patients • Healthy volunteers being recruited by advertisement • No gene/metabolic data yet

  6. BMI distributions of UC and CD

  7. Conclusions to date • There does seem to be an overweight subgroup in CD +/- UC • SNP analysis may give us evidence that some of the overweight patients have IBD as a manifestation of the metabolic syndrome