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Steve Holmes, PhD Director, Therapeutic Targets Kymab Limited. I am in the Biotechnology industry. Each gene Can be translated Into a specific protein. DNA. Proteins are large and complex and carry out the body’s functions. A code Organised into genes >30,000 in each of us.

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i am in the biotechnology industry
I am in the Biotechnology industry

Each gene

Can be translated

Into a specific

protein

DNA

Proteins are large

and complex

and carry out the body’s

functions

A code

Organised into genes

>30,000 in each of us

Most biological medicines

are PROTEINS

1

slide3

-Interferon

Biologics : Some of the Molecules used in Medicine

Biologics. Some of the Molecules

MW ca. 18,500

Aspirin MW 180

IgG Monoclonal Antibody

MW ca. 160,000

Insulin

MW ca. 6,000

pharmaceutical product sales
Pharmaceutical Product Sales

Total Sales $Billion

Top 10 - Sales $Billion

  • By 2014 Biologics are expected to account for 75% ($50Bn) of the revenues from the top 10 best selling drugs
  • Five of the Top 10 are predicted to be monoclonal antibodies
slide5

Monoclonal Antibody

Mechanism of Action of Monoclonal Antibodies

Unique binding

function

Effector function

slide6

Clinically Approved anti-TNF

Monoclonal Antibodies for RA

Remicade

Humira

Clinical use of Monoclonal Antibodies

Rheumatoid Arthritis – Disease Reversal

a day in the life of steve holmes
A day in the life of Steve Holmes
  • Research ideas for monoclonal antibody therapy for Amyotrophic lateral sclerosisIP, literature and competition searchesReview list of experts in field
  • Prepare for meeting with Contract Manufacturing Organisation
  • Attend antibody research group meeting
  • Attend management meeting
  • Telecon with Wellcome Trust
  • Prepare project plan for new monoclonal
kymab therapeutic monoclonal antibody company life cycle idea to clinic

Ideas

Research

Development

Early clinical trials

Late clinical

trials

Approval

Kymab: Therapeutic monoclonal antibody companyLife cycle: idea to clinic

~8 years

  • What is my job in the cycle?
  • Ideas
  • Research
  • Development
  • What skills are required to do my job?
  • Immunology, biochemistry, molecular biology
  • Antibody generation, antibody engineering, cell line development and manufacturing
  • Disease biology expertise
  • Clinical trials
  • IP, Fund raising, Bus. Dev.
  • Years of experience
  • Track record
kymab therapeutic monoclonal antibody company life cycle idea to clinic1

Ideas

Research

Development

Early clinical trials

Late clinical

trials

Approval

Kymab: Therapeutic monoclonal antibody companyLife cycle: idea to clinic

~8 years

  • What skills are required to do my job?
  • Immunology, biochemistry, molecular biology

How did I gain the skills?

Post-Doc (3 years)Assistant Professor (4 years)On job training

  • Antibody generation, engineering, cell line development and manufacturing
  • Disease biology expertise
  • Clinical trials
  • IP, Fund raising, Bus. Dev.
  • Years of experience
  • Track record
kymab therapeutic monoclonal antibody company life cycle idea to clinic2

Ideas

Research

Development

Early clinical trials

Late clinical

trials

Approval

Kymab: Therapeutic monoclonal antibody companyLife cycle: idea to clinic

~8 years

  • What skills are required to do my job?
  • Immunology, biochemistry, molecular biology

How did I gain the skills?

  • Antibody generation, engineering, cell line development and manufacturing

AcademiaBiotech. and Pharma. industry

  • Disease biology expertise
  • Clinical trials
  • IP, Fund raising, Bus. Dev.
  • Years of experience
  • Track record
kymab therapeutic monoclonal antibody company life cycle idea to clinic3

Ideas

Research

Development

Early clinical trials

Late clinical

trials

Approval

Kymab: Therapeutic monoclonal antibody companyLife cycle: idea to clinic

~8 years

  • What skills are required to do my job?
  • Immunology, biochemistry, molecular biology

How did I gain the skills?

  • Antibody generation, engineering, cell line development and manufacturing

AcademiaBiotech. and Pharma. industry

  • Disease biology expertise
  • Clinical trials

30+ Patents 60+ Publications

  • IP, Fund raising, Bus. Dev.
  • Years of experience
  • Track record
kymab therapeutic monoclonal antibody company life cycle idea to clinic4

Ideas

Research

Development

Early clinical trials

Late clinical

trials

Approval

Kymab: Therapeutic monoclonal antibody companyLife cycle: idea to clinic

~8 years

  • What skills are required to do my job?
  • Immunology, biochemistry, molecular biology

How did I gain the skills?

  • Antibody generation, engineering, cell line development and manufacturing
  • Disease biology expertise
  • Clinical trials

Pharma and Biotech industry

  • IP, Fund raising, Bus. Dev.
  • Years of experience
  • Track record
kymab therapeutic monoclonal antibody company life cycle idea to clinic5

Ideas

Research

Development

Early clinical trials

Late clinical

trials

Approval

Kymab: Therapeutic monoclonal antibody companyLife cycle: idea to clinic

~8 years

  • What skills are required to do my job?
  • Immunology, biochemistry, molecular biology

How did I gain the skills?

  • Antibody generation, engineering, cell line development and manufacturing
  • Disease biology expertise
  • Clinical trials
  • IP, Fund raising, Bus. Dev.

Biotech industry

30+ Patents, 60+ publications

  • Years of experience
  • Track record
kymab therapeutic monoclonal antibody company life cycle idea to clinic6

Ideas

Research

Development

Early clinical trials

Late clinical

trials

Approval

Kymab: Therapeutic monoclonal antibody companyLife cycle: idea to clinic

~8 years

4 mAbs

Bosatria

  • What skills are required to do my job?
  • Immunology, biochemistry, molecular biology

How did I gain the skills?

  • Antibody generation, engineering, cell line development and manufacturing
  • Disease biology expertise
  • Clinical trials
  • IP, Fund raising, Bus. Dev.
  • Years of experience

30+ years

Monoclonal antibodies in clinical trialsDomantis – sold to GSK for £230M

  • Track record
slide15

Biotechnology IndustrySalary, Career path and career progression/promotion opportunities

BSc 0 – 4 years experience ~£18K - £35KPhD 0 – 4 years experience ~£20K - £50K

Career Path Science Career Career Opportunities Research Associate Marketing/Sales

Scientist Patent attorney

Senior Scientist Business Dev./CBO

Director CEO

CSO Consultant

Found own company