Multiple Sclerosis: A Disease Update. Spring 2006 PAS 646 Masters Project. Kevin M. Schuer UK College of Health Sciences Physician Assistant Program. Background. Multiple sclerosis (MS) is a chronic, long-term condition that affects the central nervous system. MS is an autoimmune disease
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PAS 646 Masters Project
Kevin M. Schuer
UK College of Health Sciences
Physician Assistant Program
Rose AS. Multiple sclerosis: an overview. Adv Neurol 1981;31:3-9.
Wide range of symptoms
Inflammation and Demyelination in the CNS
Myelin is lost in multiple areas, leaving scar tissue
called plaques or sclerosis
Different for each individual
Arm and leg weakness
Sense of touch
Diagnosed between the ages of 20 and 50
Northern European ancestry (mainly)
Asian, African, and Hispanic ancestry not immuneSigns and Symptoms
McFarlin DE, McFarland HF. Multiple sclerosis.
N Engl J Med 1982;307(19):1183-8
Polman CH, Wolinsky JS, Reingold SC.
Multiple sclerosis diagnostic criteria: three years later. Mult Scler 2005;11(1):5-12
Rose AS. Multiple sclerosis: an overview. Adv Neurol 1981;31:3-9
Trapp BD. Pathogenesis of multiple sclerosis:
the eyes only see what the mind is prepared to comprehend. Ann Neurol 2004;55(4):455-7
This is a 39-year-old WF with
15 year history MS
1. Signs of Dx in different parts of the CNS
2. Evidence of two separate exaccerbations of Dx
Multiple Sclerosis: Diagnosis, Medical Management, and Rehabilitation
(Jack S. Burks, MD and Kenneth P. Johnson, MD, Editors), Demos Medical Publishing, 2000
http://www.nmss.org research and clinical trials
http://www.nmss.org – National MS Society
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