1 / 15

Enhancing Research Preparedness and Response to Emerging Pathogens: Insights and Strategies

This comprehensive review addresses the current state of research preparedness and response to emerging infectious diseases. Key lessons learned from past outbreaks, including SARS and H1N1, highlight the importance of rapid virus identification, effective coordination among agencies, and the need for international collaboration in research efforts. The REACTing initiative is proposed as a framework to improve global research leadership and integrate diverse activities, ensuring timely responses to health crises while addressing ethical, legal, and funding considerations.

rufin
Download Presentation

Enhancing Research Preparedness and Response to Emerging Pathogens: Insights and Strategies

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. ResearchPreparedness and Response to EmergingPathogensStock-taking and Perspectives Institute of Microbiology and InfectiousDiseases Bernadette Murgue YazdanYazdanpanah Jean François Delfraissy

  2. Time-series in research Research Preparedness Funding begins Funding ends Research Response

  3. The challenge of emerging infectious diseases SARS: Severeacute respiratory syndrome , H1N1 influenza pandemic West Nile Clostridium difficile 027, Dengue fever, acute hemolytic-uremic syndrome caused by Escherichia coli, H7N9 influenza, MERS-CoV, Chikungunya

  4. SARS and H1N1: Lessonslearned • SARS: 2003 • Rapid identification of a novel virus • Rapidunderstanding of transmission; impact on response • first experience of multi-agencyresponse: WHO • H1N1 pandemic: 2009 • Unexpectedseverity, unusualsymptoms • Rapid recognition of a novel influenza virus: CDC • Lack of international research collaboration

  5. Researchresponse to the H1N1 pandemic in France 30 researchprojects - Cohort studies - Case-control studies - Serosurveys - Vaccine trials - Severe disease: ARDS - Social and Human Sciences - Diagnostics - Basic research €13m Total funding • Public: Inserm, Ministries Research and Health, ANRS • Private: Roche, GSK, FondationMérieux

  6. H1N1 response: mixed results • Strengths: more than 60 publications • Weaknessess: • Non-availibility of scientists • Shortage of social scientists • Ethical and regulatory issues • Lack of specificfunding • Obstacles to international collaboration • Communication gaps

  7. H1N1: lessonslearned • Contingency plan for researchresponse • Organization and coordination • Emergency fundingduringcrisis • Reactivity and flexibility

  8. French initiative to fight against emerging infectious diseases REACTingResearchandACTion targeting emerging infectious diseases

  9. Objectives • Improveresearchpreparedness • Integrateactivities • Improve communication • Stimulate global researchleadership • Timely initiation of research projects and funding

  10. REACTing • Not focused on one particular disease • Emerging human and zoonotic infections • Not focused on a particular area of research • Surveillance, modelling, economics, communication etc. • Not focusedon northern countries • Platforms, surveillance etc. in Southern countries

  11. REACTing: a consortium IBEID HIDDEN SPIL/CMIT

  12. Researchpreparedness • Set up a governance: reactivity, flexibility • Preparation of research tools • Identification of research priorities: likely scenarios of emergence • Establishment of links between different disciplines • Identification of potential sources offunding • Anticipation of legal and ethical issues

  13. In times of crisis… • CoordinateResearch • Definestrategicpriorities • Providemethodological assistance • Respondto requests of relevant authorities • Providecomprehensiveinformation to the public • Additionalfunding

  14. In at the deep end!Chikungunya in the Caribbean 2013 • First cases: December5th (St. Martin) • First meeting: December 20th • Working groups implemented • Researchprioritiesidentified • Seed money secured First record of autochtonoustransmission in the New world

  15. What’snext? H7N9? H10N8? Others?

More Related