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Research Preparedness and Response to Emerging Pathogens Stock- taking and Perspectives. Institute of Microbiology and Infectious Diseases Bernadette Murgue Yazdan Yazdanpanah Jean François Delfraissy. Time-series in research. Research Preparedness. Funding begins. Funding ends.

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research preparedness and response to emerging pathogens stock taking and perspectives

ResearchPreparedness and Response to EmergingPathogensStock-taking and Perspectives

Institute of Microbiology and InfectiousDiseases

Bernadette Murgue

YazdanYazdanpanah

Jean François Delfraissy

slide2

Time-series in research

Research Preparedness

Funding begins

Funding

ends

Research Response

the challenge of emerging infectious diseases
The challenge of emerging infectious diseases

SARS: Severeacute

respiratory syndrome ,

H1N1 influenza pandemic

West Nile

Clostridium difficile 027,

Dengue fever,

acute hemolytic-uremic syndrome caused by Escherichia coli,

H7N9 influenza,

MERS-CoV,

Chikungunya

sars and h1n1 lessons learned
SARS and H1N1: Lessonslearned
  • SARS: 2003
    • Rapid identification of a novel virus
    • Rapidunderstanding of transmission; impact on response
    • first experience of multi-agencyresponse: WHO
  • H1N1 pandemic: 2009
    • Unexpectedseverity, unusualsymptoms
    • Rapid recognition of a novel influenza virus: CDC
    • Lack of international research collaboration
slide5

Researchresponse to the H1N1 pandemic in France

30 researchprojects

- Cohort studies

- Case-control studies

- Serosurveys

- Vaccine trials

- Severe disease: ARDS

- Social and Human Sciences

- Diagnostics

- Basic research

€13m Total funding

  • Public: Inserm, Ministries Research and Health, ANRS
    • Private: Roche, GSK, FondationMérieux
h1n1 response mixed results
H1N1 response: mixed results
  • Strengths: more than 60 publications
  • Weaknessess:
    • Non-availibility of scientists
    • Shortage of social scientists
    • Ethical and regulatory issues
    • Lack of specificfunding
    • Obstacles to international collaboration
    • Communication gaps
h1n1 l essons learned
H1N1: lessonslearned
  • Contingency plan for researchresponse
  • Organization and coordination
  • Emergency fundingduringcrisis
  • Reactivity and flexibility
objectives
Objectives
  • Improveresearchpreparedness
    • Integrateactivities
    • Improve communication
    • Stimulate global researchleadership
  • Timely initiation of research projects and funding
reacting
REACTing
  • Not focused on one particular disease
    • Emerging human and zoonotic infections
  • Not focused on a particular area of research
    • Surveillance, modelling, economics, communication etc.
  • Not focusedon northern countries
    • Platforms, surveillance etc. in Southern countries
reacting a consortium
REACTing: a consortium

IBEID

HIDDEN

SPIL/CMIT

slide12

Researchpreparedness

  • Set up a governance: reactivity, flexibility
  • Preparation of research tools
  • Identification of research priorities: likely scenarios of emergence
  • Establishment of links between different disciplines
  • Identification of potential sources offunding
  • Anticipation of legal and ethical issues
in times of crisis
In times of crisis…
  • CoordinateResearch
  • Definestrategicpriorities
  • Providemethodological assistance
  • Respondto requests of relevant authorities
  • Providecomprehensiveinformation to the public
  • Additionalfunding
in at the deep end chikungunya in the caribbean 2013
In at the deep end!Chikungunya in the Caribbean 2013
  • First cases: December5th (St. Martin)
  • First meeting: December 20th
  • Working groups implemented
  • Researchprioritiesidentified
  • Seed money secured

First record of autochtonoustransmission in the New world

what s next

What’snext?

H7N9?

H10N8?

Others?