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Graphical Abstract. Plasma Membrane. Inhibition of ATPase domain of Hu-TopoII α leads to DNA damage. (1,4-benzoquinone or 1,4-naphthoquinone , 1,2-naphthoquinone or 9,10-phenanthroquinone). Cytoplasm. TopoII α -DNA complexes. Topo II cleaves DNA and religates using ATP. DNA DSBs.
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Graphical Abstract Plasma Membrane Inhibition of ATPase domain of Hu-TopoIIα leads to DNA damage (1,4-benzoquinone or 1,4-naphthoquinone , 1,2-naphthoquinone or 9,10-phenanthroquinone) Cytoplasm TopoIIα-DNA complexes Topo II cleaves DNA and religates using ATP DNA DSBs Nucleus Topo II binds to DNA Histones DNA Repair Phosphorylation of histones Cell Survival DNA damage, chromosomal aberrations P P P P Cancer